Comparison of clinical efficacy of praziquantel of different doses in the treatment of chronic schistosomiasis
LI Chaoqun1, LUO Dan2, YANG Xin3, MA Ranping4, ZHANG Baoxin5, JIAN Ming6
1.Department of Pharmacy,2.Department of Clinical Laboratory,5. Department of Medical Affairs,6. Hospital Office,Hunan Provincial corps Hospital of Chinese People’s Armed Police Force,Changsha 410006,China; 3. Chenzhou Hospital, Chinese People’s Armed Police Force,Chenzhou 423000,China;4. Department of Hygiene,Logistic University of Chinese People’s Armed Police Force,Tianjin 300162,China
Abstract：Objective To explore the effect of doses on the efficacy of praziquantel in the treatment of chronic schistosomiasis.Methods Ninety patients treated at Hunan Corps Hospital of the Armed Police were randomly divided into two groups. In the low-dose group, 45 patients were given praziquantel at a dose of 40 mg/kg, while in the conventional-dose group the 45 patients were given a conventional dose of 60 mg/kg. Both groups took the drug two or three times a day for two days, two groups were compared.Results The efficacy of low-dose group and the conventional-dose group was roughly equal.The efficacy, usage of liver-protecting drugs, and adverse reaction rates were not significantly different between the two groups (P>0.05).Conclusions Low-dose praziquantel is as effective as conventional-dose praziquantel and can reduce the usage of praziquantel.
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LI Chaoqun, LUO Dan, YANG Xin, MA Ranping, ZHANG Baoxin, JIAN Ming. Comparison of clinical efficacy of praziquantel of different doses in the treatment of chronic schistosomiasis. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(11): 1062-1064.
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2018, Vol. 29 
