Abstract：Objective To study the difference of clinical and laboratory findings between children with moderate and severe hypoxic-ischemic encephalopathy (HIE) and those with non-moderate-severe HIE in order to remind clinicians of early detection of moderate-severe HIE in infants and interventions.Methods The clinical data on eighty cases of asphyxia treated in our department between January 1, 2013 and December 31, 2014 was retrospectively analyzed.These patients were divided into non-moderate-severe HIE group and moderate-severe HIE group. Clinical factors and laboratory results were compared between the two groups. SPSS 17.0 software was used for statistical analysis, and P<0.05 was considered statistically significant.Results Seventy-two cases were enrolled, fourteen with moderate-severe HIE, and fifty-eight with non-moderate-severe HIE. (1) Apgar scores at 1 minute, 5 minutes and 10 minutes after birth, arterial blood gas analysis at 1 hour after birth, PH, BE and HCO-3 concentrations in both groups were significantly different between the two groups(P<0.05), but not in partial pressure of oxygen PO2)or partial pressure of carbon dioxide (PCO2) (P>0.05). (2) The incidence of seizures, the abnormal rate of amplitude integrated electroencephalogram (aEEG) within 3 days after birth and abnormal blood glucose, renal dysfunction, abnormal myocardial enzymes, incidence of abnormal digestive tracts, the proportion of patients in need of mechanical ventilation were higher in the moderate-severe HIE group than in the non-moderate-severe HIE group (P<0.05). (3) Alanine aminotransferase (ALT), aspartate aminotransferase (AST), prealbumin, total bilirubin, direct bilirubin, and total bile acids were not significantly different between the two groups 12-24 hours after birth (P> 0.05).Conclusions Low Apgar scores, severe acidosis suggested by arterial blood gas about 1h after birth, and complications with multiple organ dysfunction indicate that moderate to severe HIE may occur in children with asphyxia. Enzymatic liver indicators and indicators of reaction cholestasis are not closely correlated with moderate and severe HIE.
Use and abuse of the Apgar score. Committee on Fetus and New born, American Academy of Pediatrics, and Committee on Obstetric Practice, American College of Obstetricians and Gynecologists[J]. Pediatrics, 1996, 98(1):141 - 142.
2018, Vol. 29 
