Effect of controlled decompression on reperfusion injury in patients with craniocerebral trauma
LEI Zhiheng1,2
1.Department of Neurosurgery, the First College of Clinical Medical Science, China Three Gorges University, Yichang 443000, China; 2. Department of Neurosurgery, Yichang Central People’s Hospital, Yichang 443000, China
Abstract：Objective To explore the effect of controlled decompression on reperfusion injury in patients with craniocerebral trauma.Methods One hundred patients with craniocerebral traum treated in our hospital between March 2014 and March 2017 were selected as subjects. According to the therapeutic method, these patients were divided into the pressure control group (50 cases) and the standard pressure group(50 cases). The pressure control group was treated with controlled decompression, while the standard pressure group was treated with standard decompression. The levels of interleukin -6 (IL-6), ischemia modified protein (IMA), neuron specific enolase (NSE), treatment efficacy, complications and death rate were compared between the two groups.Results After operation, levels of serum IL-6, IMA, and NSE of the two groups were significantly lower, especially in the pressure control group, and the difference was statistically significant (P<0.05). The effective rate of treatment of the pressure control group (96.0%) was significantly higher than that of the standard pressure group(78.0%), and the difference was statistically significant (P<0.05). The rate of complications of the pressure control group (8.0%) was significantly lower than that of the standard pressure group(30.0%), and the difference was statistically significant (P<0.05). But the mortality of the two groups was basically the same.Conclusions Controlled decompression can effectively improve cerebral oxygen uptake in patients with craniocerebral trauma, reduce reperfusion injury and complications, so it’s worthy of clinical promotion.
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2018, Vol. 29 
