Effects of atovastatin and ginkgo biloba preparations on cerebral blood flow parameters and carotid atherosclerotic plaque indexes in patients with cerebral infarction
SONG Bo1, SUN Yukun1, HE Wei1, SONG Yang2, TANG Zhe1, ZHU Hongxia3, WANG Haipeng1, and SU Hong4
1. Department of Pharmacy and Equipment, 3. Department of Internal Medicine, 4. Department of General Surgery, Liaoning Provincial Corps Hospital of Chinese People’s Armed Police Force, Shenyang 110034, China; 2.Healthcare Team of Army 93321, Shenyang 110034,China
Abstract：Objective To investigate the effect of atovastatin and ginkgo biloba preparations on cerebral blood flow parameters and carotid atherosclerotic plaque indexes in patients with cerebral infarction.Methods Two hundred and thirty-five patients with cerebral infarction were selected in our hospital. The patients were divided into two groups according to the drug regimen. The control group (n=116) was treated with atovastatin while the experimental group (n=119) was additionally given ginkgo biloba preparations. The changes of carotid atherosclerotic plaques, cerebral hemodynamic parameters and hemorheological indexes were compared before and after treatment. Adverse reactions were also recorded.Results In the experimental group, the hemodynamic indexes RI(0.52±0.17) and PI(0.91±0.24) were significantly lower than in the control group, while Vd(37.29±2.82)cm/s, Vs(81.33±3.58)cm/s and Vm(9.78±1.22) cm/s were significantly higher (P＜0.05). In the experimental group, the plaque area of posterior carotid atherosclerosis (0.52±0.12)cm2, CAIMT(1.26±0.17)mm was significantly smaller than that of the control group (P＜0.05) after treatment. There was no significant difference in the rate of adverse reactions between the two groups.Conclusions For patients with cerebral infarction, atovastatin combined with ginkgo biloba preparations can effectively promote the recovery of hemorheological indexes and hemodynamic parameters and improve carotid atherosclerotic plaques. This approach is quite safe.
宋博, 孙玉坤, 何伟, 宋旸, 唐哲, 朱红霞, 王海鹏, 苏宏. 阿托伐他汀联合银杏叶对脑梗死患者脑血流参数和颈动脉粥样硬化斑块的影响[J]. 武警医学, 2018, 29(5): 500-503.
SONG Bo, SUN Yukun, HE Wei, SONG Yang, TANG Zhe, ZHU Hongxia, WANG Haipeng, and SU Hong. Effects of atovastatin and ginkgo biloba preparations on cerebral blood flow parameters and carotid atherosclerotic plaque indexes in patients with cerebral infarction. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(5): 500-503.
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2018, Vol. 29 
