Goal-directed fluid therapy in hemorrhagic shock rabbits guided by pressure recording analytical method
LIU Xiaomei1, MA Li1, DONG Lan2
1. Department of Anesthesiology,Sixth Medical Center of PLA General Hospital,Beijing 100048, China; 2. Department of Anesthesiology, the third Medical Center of PLA General Hospital,Beijing 100039, China
Abstract：Objective To evaluate the therapeutic effect of the goal-directed fluid therapy guided by pressure recording analytical method(PRAM)against hemorrhagic shock rabbits.Methods Forty hemorrhagic shock rabbits were randomly divided into two groups:goal-directed fluid therapy group (group G) and the traditional fluid therapy group(group C),with 20 cases in each.The total fluid intake, crystal fluid intake, colloid fluid intake, autologous blood input, urine volume, vasoactive drug usage, and animal deaths during fluid therapy were recorded.The hemodynamic indexes and blood gas values were calculated beforemodeling (T0), upon hemorrhagic shock (T1), 30 minutes after liquid treatment (T2), 60 minutes afterliquid treatment (T3), and 90 minutes afterliquid treatment(T4).Results Compared with group C, the total fluid intake, crystalloid intake and autologous blood input in group G decreased, while the colloidal fluid intake and urine output increased, with statistically significant difference (P<0.05).Two patients in group G and five patients in group Ctook vasoactive drugs.Compared to group C,MAP,PaO2 and BE were significantly increased in groupGat T2 and T3,while HR,pH,PaCO2 and Lac were significantly decreased.Inboth groups,MAP,HR,PaO2,pH and BE were more significantly increased at T2 to T4 than at T1,while MAP,PaO2,pH and BE were more significantly decreased at T2 and T3 than at T0, but HR,PaCO2 and Lac were more significantly increased than at T0 (P<0.05).Conclusions The goal-directed fluid therapy guided by pressure recording analysis method has advantages over traditional fluid therapies in that this approach can improve hemodynamic status, ameliorate metabolic acidosis, optimize the fluid input and fluid ratio, and reduce autologous blood inputs.
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2020, Vol. 31 
