Shen N, Mo L Q, Hu F, et al. A novel role of spinal astrocytic connexin 43: mediating morphine antinociceptive tolerance by activation of NMDA receptors and inhibition of glutamate transporter-1 in rats[J].CNS Neurosci Ther, 2014, 20(8): 728-736.
[2]
Marcus D J, Zee M, Hughes A, et al. Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase[J].Mol Pain, 2015, 11(1): 34.
[3]
Robinson C R, Dougherty P M. Spinal astrocyte gap junction and glutamate transporter expression contributes to a rat model of bortezomib-induced peripheral neuropathy[J]. Neuroscience, 2015, 285: 1-10.
[4]
Freitas-Andrade M, Wang N, Bechberger J F, et al. Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke[J].J Exp Med, 2019, 216(4): 916-935.
[5]
Tonkin R S, Mao Y, O’Carroll S J, et al. Gap junction proteins and their role in spinal cord injury[J].Front Molec Neurosci, 2015, 7: 102.
[6]
Wang A, Xu C. The role of connexin43 in neuropathic pain induced by spinal cord injury[J]. Acta Biochim Biophy Sin, 2019, 51(6): 555-561.
[7]
Epifantseva I, Shaw R M. Intracellular trafficking pathways of Cx43 gap junction channels[J]. Biochim Biophys Act, 2018, 1860(1): 40-47.
[8]
Hang L H, Li S N, Luo H, et al. Connexin 43 mediates CXCL12 production from spinal dorsal horn to maintain bone cancer pain in rats[J].Neurochem Res, 2016, 41(5): 1200-1208.
[9]
Chen M J, Kress B, Han X, et al. Astrocytic Cx43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury[J]. Glia, 2012, 60(11): 1660-1670.
[10]
Spray D C, Hanani M. Gap junctions, pannexins and pain[J].Neurosci.Lett, 2017.
[11]
Yang H, Yan H, Li X, et al. Inhibition of connexin 43 and phosphorylated NR2B in spinal astrocytes attenuates bone cancer pain in mice[J].Front Cell Neurosci, 2018, 12: 129.
[12]
Morioka N, Miyauchi K, Miyashita K, et al. Spinal high-mobility group box-1 induces long-lasting mechanical hypersensitivity through the toll-like receptor 4 and upregulation of interleukin-1β in activated astrocytes[J].J Neurorochem, 2019.
[13]
Choi S R, Roh D H, Yoon S Y, et al. Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice[J]. Neuropharmacology, 2016, 111: 34-46.
Li Q Y, Xu H Y, Yang H J. Effect of proinflammatory factors TNF-α, IL-1β, IL-6 on neuropathic pain[J].J Chin Mater Med, 2017, 42(19): 3709-3712.
[16]
Lastwika K J, Dunn C A, Solan J L, et al. Phosphorylation of connexin43 at MAPK, PKC or CK1 sites each distinctly alter the kinetics of epidermal wound repair[J].J Cell Sci, 2019,21(5): 234633.
[17]
Morioka N, Zhang F F, Nakamura Y, et al. Tumor necrosis factor-mediated downregulation of spinal astrocytic connexin43 leads to increased glutamatergic neurotransmission and neuropathic pain in mice[J].Brain Behav Immun, 2015, 49: 293-310.
[18]
Deng M, Chen S R, Chen H, et al. Mitogen-activated protein kinase signaling mediates opioid-induced presynaptic NMDA receptor activation and analgesic tolerance[J].J Neurochem, 2019, 148(2): 275-290.
Sanna M D, Ghelardini C, Galeotti N. Activation of JNK pathway in spinal astrocytes contributes to acute ultra-low-dose morphine thermal hyperalgesia[J]. Pain, 2015, 156(7): 1265-1275.
Qian Y, Wang Q, Jiao J, et al. Intrathecal injection of dexmedetomidine ameliorates chronic neuropathic pain via the modulation of MPK3/ERK1/2 in a mouse model of chronic neuropathic pain[J].Neurol Res, 2019: 1-10.
Caraci F, Merlo S, Drago F, et al. Rescue of noradrenergic system as a novel pharmacological strategy in the treatment of chronic pain: focus on microglia activation[J].Front Pharmacol, 2019, 10.