Abstract：Objective To explore the effect of high intensity focused ultrasound (HIFU) and uterine artery embolization (UAE) on ovarian reserve function during the treatment of cesarean scar pregnancy (CSP). Methods One hundred and forty-two patients with CSP Ⅱ treated between January 2013 and June 2018 were selected. According to pretreatment methods, these patients were divided into two groups: the HIFU group (n=96) in which HIFU was used and the UAE group (n=46) where UAE was used. After pretreatment, hysteroscopy and laparoscopy were performed. The levels of serum estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), anti-mullerian hormone (AMH) and the change of antral follicle count (AFC) were observed before operation and 3, 6 and 12 months after operation. These patients were followed up in order to record the side effects. Results (1) There was no statistically significant difference in AMH, FSH, LH, E2 or AFC between patients in the HIFU group at different time points. (2) In the UAE group, there was no significant difference in E2 between these patients before or after operation. However, AMH and AFC were significantly lower after 3, 6, 12 months. FSH and LH were significantly higher after 3 months and 6 months, and the difference was statistically significant (P<0.05). (3) There was no significant difference in AMH, FSH, LH, E2 or AFC between the two groups before operation. AMH and AFC in the UAE group were significantly decreased 3 and 6 months after operation compared with the HIFU group at the corresponding time points. However, FSH and LH levels increased, and the difference was statistically significant (P<0.05). (4)Menstrual recovery rates in the HIFU group and UAE group were 98.9% and 91.3% respectively 5 weeks after operation. The difference between the two groups was statistically significant (P<0.05). There was no significant difference in the recovery rate of blood β-HCG between the two groups 4 weeks after operation. Conclusions HIFU is safe, effective, non-invasive and repeatable during the treatment of CSP, which does not affect ovarian reserve function. HIFU is of special significance for CSP patients who hope for reproduction.
王雅慧, 李全香, 杨娜, 付琳琳. 高强度聚焦超声治疗瘢痕妊娠对卵巢储备功能的影响[J]. 武警医学, 2020, 31(5): 378-381.
WANG Yahui, LI Quanxiang, YANG Na, FU Linlin. Effect of high intensity focused ultrasound on ovarian reserve function during the treatment of scar pregnancy. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(5): 378-381.
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2020, Vol. 31 
