Abstract：Objective To study the changes of serum calcium levels in patients with acute coronary syndrome (ACS), and to explore the correlations between serum calcium and acute myocardial infarction (AMI). Methods A total of 247 ACS patients who were admitted to the Department of Cardiology, Beijing Tiantan Hospital, between June 2019 and July 2019 were enrolled. The clinical data on these patients was collected. Blood samples were drawn to measure serum calcium levels and other biochemical parameters. Binary Logistic regression was used to analyze the risk factors for AMI. Results The 247 ACS patients were divided into two groups: the unstable angina pectoris group (n=149) aged (62.88±9.91) years and the AMI group (n=98) aged (60.21±10.86) years. The serum calcium level in the AMI group (2.21±0.11) mmol/L was significantly lower than that of the unstable angina group (2.25±0.09) mmol/L (P<0.001). Logistic regression analysis showed that after adjusting for confounding factors such as gender, heart rate, serum albumin, total cholesterol and blood phosphorus, the quartile of serum calcium (OR 0.591, 95% CI 0.399-0.874,P=0.008), age (OR 0.834, 95% CI 0.791-0.898, P<0.001), hemoglobin (OR 1.048, 95% CI 1.017-1.079, P=0.002), low density lipoprotein cholesterol (OR 2.532,95% CI 1.544-4.151, P<0.001) and GRACE score (OR 1.129, 95% CI 1.092-1.167, P<0.001) were independent risk factors for AMI. Conclusions Compared with patients with unstable angina pectoris, AMI patients may show lower levels of serum calcium. A reduced level of serum calcium is an independent risk factor for AMI.
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2022, Vol. 33 
