Therapeutic effect of traditional Chinese medicine decoction combined with glucocorticoid in treatment of subclinical thyroiditis
YANG Wujun1, WANG Shanfu2, HAN Feng2, ZHANG Chao3, HU Qiancheng4, LU Guangxu5
1. Economic Maregenent Departent,3. Outpatient Department, 4. Department of Traditional Chinese Medicine, 5. The First Department of Surgery;the Second Mobile Corps Hospital of Chinese People’s Armed Police Force, Wuxi 214000, China;2. The First Departement of Surgery,the First Mobile Corps Hospital of Chinese People's Armed Police Force, Dingzhou 073000, China
Abstract：Objective To investigate the therapeutic effect of Chinese medicine decoction combined with glucocorticoid in the treatment of subacute thyroiditis.Methods Ninety patients with subacute thyroiditis admitted to the outpatient department of endocrinology of the Second Mobile Corps Hospital of Chinese People's Armed Police Force from January 2018 to December 2020 were selected and randomly divided into western medicine group, traditional Chinese medicine group and integrated Chinese and western medicine group by envelope method, with 30 patients in each group. The western medicine group was treated with prednisone 30 g/d, the Chinese medicine group was treated with Chinese medicine decoction, and the third group used prednisone combined with Chinese medicine decoction. Thyroid function, serum immunological and inflammatory indexes of the three groups were compared before and 8 weeks after treatment, and the time of clinical symptoms disappearance and the incidence of adverse reactions during treatment were compared.Results Before treatment, there were no significant differences in thyroid function, serum immunology and inflammatory indexes among the three groups. After eight weeks of treatment, serum free triiodothyronine (FT3), free tetraiodothyronine (FT4), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb) and erythrocyte sedimentation rate in 3 groups (ESR), C-reactive protein (CRP) and interleukin-6 (IL-6) levels significantly decreased, and serum thyrotropin (TSH) levels increased, and the effect of integrated Chinese and western medicine group was better than that of traditional Chinese medicine and western medicine alone, the differences were statistically significant (P＜0.05), while there was no significant difference between the Chinese medicine group and the western medicine group. The time of clinical symptoms disappearance was shorter in integrated Chinese and western medicine group (P＜0.05). There was no significant difference in the incidence of adverse reactions among the three groups.Conclusion The combined treatment of traditional Chinese and western medicine has a better effect on subacute thyroiditis, which can relieve clinical symptoms, improve thyroid function and reduce the level of inflammatory indicators.
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YANG Wujun, WANG Shanfu, HAN Feng, ZHANG Chao, HU Qiancheng, LU Guangxu. Therapeutic effect of traditional Chinese medicine decoction combined with glucocorticoid in treatment of subclinical thyroiditis. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(8): 693-696.
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2022, Vol. 33 
