Establishment of troponin T correction formula for non-dialysis patients with chronic renal disease
KUANG Haibo1, NIE Shanhua2, YANG Cheng3, CHEN fen3, PAN Dezhang3
1. The Fifth Central Hospital of Wuhan, Wuhan 430050, China; 2. Hubei ProvincialCorps Hospital ofChinese People’s Armed Police Force, Wuhan 430064, China; 3. Department of Nephrology, General Hospital of Central Theater Command, Wuhan 430070, China
Abstract：Objective To investigatethe relationshipbetween troponin T (cTnT) and common clinical indicators in patients with chronic kidney disease (CKD), and to establish a correction formula for cTnT in non-dialysis CKD patients. Methods TheClinical indicators of 690 non-dialysis hospitalized CKD patients were retrospectively analyzed,including age, sex, basal metabolic rate (BMI), estimated glomerular filtration rate (eGFR), serum creatinine (CR), serum uric acid (UA), blood urea nitrogen (BUN), albumin (ALB), cholesterol (CHOL), triglyceride (TG), hemoglobin (HGB), hematocrit (HCT), red blood cell distribution width (RDW), red blood cell count (RBC), CKD stage. The logarithm of cTnT value was taken as ln(cTnT), the dependence between ln (cTnT) and the above indexes was discussed, and the correction formula of cTnT was established. Results The abnormal rate of cTnT increased gradually with the increase of CKD stage. The cTnT levels of each stage of CKD were significantly different (P<0.05). ln(cTnT) was linearly correlated with CR, UA, BUN, HGB, ALB, HCT, RDW, RBC, CKD stage, age and eGFR (P<0.05). With CR, HGB, HCT, RBC, CKD stage there was strong correlation(| R | >0.5). Stepwise multiple linear regression analysis was adopted, and the final correction formula was cTnTcalibration=0.0124×1.3366CKD×0.9931HGB. Conclusions In the clinical investigation of acute coronary syndrome(ACS) in non-dialysis CKD patients, cTnT detection value can be compared with cTnT calibration before judgment.
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KUANG Haibo, NIE Shanhua, YANG Cheng, CHEN fen, PAN Dezhang. Establishment of troponin T correction formula for non-dialysis patients with chronic renal disease. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(11): 977-980.
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2023, Vol. 34 
