Application value of CT quantitative analysis in antisynthetase syndrome complicated with interstitial pneumonia
DING Mengjiang1, LI Xueren2, PENG Shouchun2, ZHANG Yuhua3
1. Department of Medicine, Tianjin Municipal Corps Hospital of Chinese People's Armed Police Force, Tianjin 300162, China; 2. Department of Respiratory Medicine, Jinnan Hospital of Tianjin, Tianjin 300350, China; 3. Department of Respiratory Medicine, Characteristics Medical Center of Chinese People's Armed Police Force, Tianjin 300162, China
Abstract：Objective To explore the application value of CT quantitative analysis in antisynthetase syndrome complicated with interstitial pneumonia(ASS-ILD).Methods The clinical data of 42 patients with ASS-ILD admitted to the respiratory department of Characteristics Medical Center of Chinese People's Armed Police Force from January 2015 to June 2022 were retrospectively analyzed. Quantitative software was used to automatically analyze CT images to the total lung volume (TLV) and mean lung attenuation (MLA), caculate the volume and weight of different regions and their percentage in the total lung volume, and then analyze the correlation between CT quantitative indexes and PFT parameters. CT quantitative indexes of nonspecific interstitial pneumonia with organizing pneumonia (NSIP/OP) and organizing pneumonia (OP) were compared and analyzed.Results FVC% and FEV1% were positively correlated with -500 HU to -100HU area (r＝0.58, P＝0.048; r＝0.79, P＝0.01), FEV1/FVC was negatively correlated with -950 HU to -500 area (r＝-0.23, P＝0.01), with statistical significance (P<0.05). The bad ventilation volume (Vfibrosis%) in the NSIP/OP group was significantly higher than that in the OP group (P＝0.03), and the carbon monoxide diffusion capacity (DLCO%) was significantly lower than that in the OP group (P＝0.01). The volume of hyperventilation (Vhyper%) and weight of hyperventilation (Whyper%) in the OP group were higher than those in the NSIP/OP group (P<0.05). The total lung average failure value (MLAtotal) in the NSIP/OP group was significantly higher than that in the OP group (P<0.01).Conclusions There is a good correlation between HRCT quantitative analysis and PFT parameters, which can be used to evaluate lung function, and has reference value for NSIP/OP and OP type determination.
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2024, Vol. 35 
