Abstract： Objective To analyze thyroid function changes in severe burn patients and to evaluate the thyroid function testing in treatment of burn patients. Methods 114 severe burn patients in this hospital from July 2007 to April 2012 were recruited. The five items of thyroid function testing on day 1, 3, 5, 7, 14, and 20 were conducted. According to the age, the patients were divided into the elderly group, middle aged group and young group, with 30 healthy subjects as control group. Automatic detecting instrument of chemiluminescence analyzer Centaur CP was used. Results Serum FT3, FT4 values in elderly group were significantly lower than in the control group (P<0.05 or P<0.01). Serum FT3 began to decline from day 1, serum FT4 began to decline from day 3; and the serum TSH, aTG, aTPO values were higher than those in the control group (P<0.05 or P< 0.01), in which the value of serum TSH reach the peak on day 7. Five results of severe burn patients in middle age group compared with the control group had no significant differences, serum aTG, aTPO had a tendency to rise. Serum FT3, FT4, TSH values in severe burn children group compared with the control group had no significant difference, and the serum aTG, aTPO values compared with the control group increased (P<0.01), in which the aTPO value increased more markedly. Conclusions It is important to test thyroid function changes in severe burn patients.
王宏宇, 樊毫军, 杨 炯, 等 .高温高强度阅兵集训对甲状腺激素的影响［J］.武警医学, 2011, 22（10）: 846-848.［2］ 杨向红, 孙仁华, 徐云祥, 等. 危重患者血清甲状腺素和细胞因子变化的研究［J］.临床医学, 2003, 23（2）: 6-8.［3］ 陆建红, 陈国军, 金晓东, 等. 危重病患者血清降钙素原和甲状腺激素测定的意义［J］.武警医学, 2008, 19（3）: 221-224. ［4］ Thienpont L M, Van Uytfanghe K, Beastall G, et al. Report of the IFCC Working Group for Standardization of Thyroid Function Tests［J］. Clin Chem, 2010, 56（4）: 912-920.［5］ Bresee J, Fang Z Y, Wang B, et al. First report from the Asian Rotavirus Surveillance Network［J］. Emerg Infect Dis, 2004, 10（6）: 974-998.［6］ 连小兰.评析《甲状腺疾病诊断治疗中实验室检测项目的应用建议》［J］.中华检验医学杂志, 2012, 35（6）: 509-510.［7］ 宋 新, 刘向祎, 文江平, 等. 北京和上海地区部分健康人群血清甲状腺激素参考区间的初步调查［J］. 中华检验医学杂志, 2012, 35（2）: 156-159.
2013, Vol. 24 
