Association of IL-6 gene promoter region -643C/G polymorphism with diabetic retinopathy
AN Xinhuan1,LANG Ganxiong1, and WU Huijuan2
1.Department of Diabetes,Zhongshan People’s Hospital, Zhongshan 528400, China; 2. Beijing Physical and Chemical Analysis and Testing Center, Beijing 100094,China
Abstract：Objective To investigate the association of IL-6 gene promoter region -643C/G polymorphism with diabetic retinopathy. Methods The polymorphism of IL-6 gene promoter region -634 C/G in 245 unrelated Guangdong Han people with type 2 diabetes ,including 153 cases without diabetic retinopathy (DR0 group) ,51 cases without proliferative diabetic retinopathy (NPDR)(DR1 group), 41 cases with proliferative diabetic retinopathy (PDR) (DR2 group), and 101 normal controls(NC group) were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. The genotype frequency, allele frequency and relative clinical data were compared between groups. Results (1)There were no significant differences in the clinical characteristics except for diabetic duration among DR0, DR1, DR2 groups. (2) The frequencies of IL-6-643 G/G genotype and G allele frequencies among DR0 DR1 DR2 groups were statistically different. There were significantly different in GG genotype between DR0 and DR group,comparison between any two means were not significant differences in G allele frequencies.(3) Logistic regression analysis showed that IL-6 gene promoter region-643G/G genotype,fasting plasma glucose and diabetic duration were risk factors of DR. Conclusions The IL-6 promoter region-643G/G genotype may be a genetic risk factor of DR development.
安新焕,梁干雄,武会娟. IL-6基因启动子区-634C/G多态性与糖尿病视网膜病变的关系[J]. 武警医学, 2014, 25(11): 1085-1088.
AN Xinhuan,LANG Ganxiong, and WU Huijuan. Association of IL-6 gene promoter region -643C/G polymorphism with diabetic retinopathy. Med. J. Chin. Peop. Armed Poli. Forc., 2014, 25(11): 1085-1088.
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Funatsu H, Yamashita H, Noma H, et al.Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients[J].Graefes Arch Clin Exp Ophthalmol,2005,243(1):3-8.
Carin, Gustavsson,Carl D,et al.Profile of intraocular tumour necrosis factor-α and interleukin-6 in diabetic subjects with different degrees of diabetic retinopathy [J]. Acta ophthalmologica, 2013,91(5):445-452.
2014, Vol. 25 
