Abstract：Objective To evaluate the clinical significance of serum D-dimer and C-reactive protein (CRP) detection in patients with colorectal carcinoma. Methods Fifty-three patients and thirty healthy controls were enrolled and bloods were sampled from controls at examination and patients pre-operation and on days 1, 3, 7 post-operation respectively. Serum D-dimer and CRP were detected. The results were analyzed considering the pathologic parameters such as TNM staging, lymph nodes metastasis and vascular invasion. Contrastive analyses were performed between the measurements of laparoscopic and open resection cases. Results D-dimer and CRP levels in patients were significantly higher than in controls(P＜0.01). D-dimer and CRP levels in patients with lymph nodes metastasis or vascular invasion were significantly higher than in negative cases. Serum D-dimer and CRP were increased by the TNM stages promotion. Serum D-dimer and CRP were both increased post-operation and then decreased. D-dimer was attenuated to normal level and CRP was still significantly higher than pre-operation at 7 days post-operation. CRP in patients undergoing laparoscopic resection were significantly lower than in those undergoing open resection. Pre-operative CRP and D-dimer were positively correlated(r=0.432,P＜0.05). Conclusions Serum D-dimer and CRP are correlated with pathologic degrees in CRC; combined measurements of these two indexes may be significant in early diagnosis, prognosis and post-operative inflammation judgment in CRC.
柳庆华,许方程,宝彩芹,李永芬,马佳. 结直肠癌患者血清D-dimer与C-反应蛋白的检测及其临床意义[J]. 武警医学, 2014, 25(11): 1089-1091.
LIU Qinghua, XU Fangcheng, BAO Caiqin, LI Yongfen, and MA Jia. Detection of serum D-dimer and CRP in patients with colorectal cancer and its clinical significance. Med. J. Chin. Peop. Armed Poli. Forc., 2014, 25(11): 1089-1091.
Poullis A, Foster R, Shetty A, et al. Bowel inflammation as measured by fecal calprotectin : a link between lifestyle factors and colorectal cancer risk[J]. Cancer Epidemiol Biomarkers Prev,2004,13(2):279-284.
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2014, Vol. 25 
