Abstract：Objective To evaluate the outcome of low molecular weight heparin (LMWH) for the prevention of lower extremity deep vein thromboembolism (LDVT) in patients with hypertensive intracerebral hemorrhage after operation. Methods 82 patients with hypertensive intracerebral hemorrhage after operation were divided into two groups: prothylactic group (n=42) and control group (n=40). The patients in prothylactic group were injected hypodermically with LMWH from day 3 to day 14 after operation and treated with intermittent pneumatic compression from 1 to 21 days continuously. Whereas the patients in control group were treated only by intermittent pneumatic compression. The plasma D-dimer (D-D) was measured in all patients before operation and was determined at day 7, 14, 21 after operation. The deep veins of lower limbs in all patients were examined with colour Doppler at day 7, 14, 21 after operation to observe venous thromboembolism. Results Only one case of deep vein thrombosis in prothylactic group(2.38%), and one cerebral hemorrhage(2.38%)recurred. In control group, deep vein thrombosis was found in 9 cases(22.50%), and one cerebral hemorrhage(2.50%) recurred, and one pulmonary embolism(2.50%)was found. The DVT incidence between two groups was significantly different(P＜0.05), but the PTE incidence was not significantly different. D-D content at days 7, 14 after operation in control group was significantly higher than that in prophylactic group (P＜0.05), but the D-D level had no significant difference before operation and at day 21 after operation between the two groups. Conclusions LMWH is safe and effective for the prevention of LDVT in patients after hypertensive intracerebral hemorrhage operation.
Gregory P C, Kuhlemeier K V. Prevalence of venous thromboembolism in acute hemorrhagic and thromboembolic stroke [J]. Am J Phys Med Rehabil, 2003, 82(5): 364-369.
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2014, Vol. 25 
