Value of blood and urine NGAL in diagnosing hypertensive nephropathy
NIU Dong1, HOU Fei2, and ZHOU Jing3
1.General Hospital of Beijing Municipal Corps, Chinese People’s Armed Police Force,Beijing,100027,China; 2.North China Grid Company Limited Beijing Electric Power Hospital,Beijing 100073,China; 3.Very Important People’s Health Care Department, General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China
Abstract：Objective To study the role of neutrophil gelatinase-associated lipocalin(NGAL) played in hypertensive nephropathy,and to identify its clinical significance. Methods 435 patients with hypertension were divided into two groups according to their course of the diseases,and in three degrees.135 healthy people were enrolled as an observation group. We detected urine NGAL levels by enzyme linked immune absorption assay,Scr、ACR、sβ2-mG and uβ2-mG were detected,too. Results The levels of urine NGAL in all subjects with hypertension were obviously higher than in the healthy people,compared with control group(0.58±0.32)μg/L,the degree 1 hypertension(1.21±0.63)μg/L and shorter course of the hypertension (2.21±1.59)μg/L showed higher urine NGAL (P＜0.05),while the 2 (1.93±1.86)μg/L and degree 3 hypertension(3.11±1.38)μg/L and longer course of the hypertension(3.29±1.41)μg/L had higher urine NGAL(P＜0.01).Urine NGAL was significantly higher in patients with degree 3 hypertension than in patients with degree 1 hypertension (P＜0.05). The longer course of the hypertension distinctly higher than the shorter(P＜0.05),too.The concentration of urine NGAL had positive relation to degree of hypertension,course of the hypertension and Scr(r=0.415,0.427,0.540,P＜0.05),no relation to ACR、serum β2-mG and urineβ2-mG. Conclusions Urine NGAL is expected to be developed as a new biomarker to diagnose hypertensive nephropathy because of its sensitive and specific character.
Haroun M K,Jaar B G,Hoffman S C,et al.Risk factors for chronic kidney disease:a prospective study of 23,534 men and women in Washington County,Maryland[J].J Am Soc Nephrol,2003,14(11):2934-2941.
Chaudhary K, Phadke G, Nistala R,et al.The emerging role of biomarkers in diabetic and hypertensive chronic kidney disease[J]. Curr Diab Rep, 2010,10(1):37-42.
[3]
Ding H,He Y,Li K,et al.Urinary neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for renal tubulointerstitial injury in IgA nephropathy[J]. Clinical Immunology, 2007,123(2):227-234.
[4]
Haroun M K,Jaar B G,Hoffman S C,et al.Risk factors for chronic kidney disease:a prospective study of 23,534 men and women in Washington County,Maryland[J].J Am Soc Nephrol,2003,14(11):2934-2941.
[7]
王海燕.肾脏病学[M].3版.北京:人民卫生出版社,2008:1662-1668.
[8]
Wu J T.Advanced glycosylation end products:8 new disease marker for diabetes and aging[J].J Clin Lab Anal,1993,7(5):252-255.
Mori K,Nakao K.Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage[J].Kidney Int,2007,71(10):967-970.
[10]
Mishra J,Mori K,Ma Q,et al.Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin[J].J Am Soc Nephrol,2014,15(12):3073-3082.
[11]
Mori K,Lee H T,Rapoport D,et al. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury[J].J Clin Invest,2005,115(3):610-621.
[7]
王海燕.肾脏病学[M].3版.北京:人民卫生出版社,2008:1662-1668.
[8]
Wu J T.Advanced glycosylation end products:8 new disease marker for diabetes and aging[J].J Clin Lab Anal,1993,7(5):252-255.
[9]
Mori K,Nakao K.Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage[J].Kidney Int,2007,71(10):967-970.
[10]
Mishra J,Mori K,Ma Q,et al.Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin[J].J Am Soc Nephrol,2014,15(12):3073-3082.
[11]
Mori K,Lee H T,Rapoport D,et al. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury[J].J Clin Invest,2005,115(3):610-621.
2015, Vol. 26 
