Abstract：Objective To study the effect of dexmedetomidine combined with nebulized lidocaine inhalation on conscious patients receiving nasotracheal intubation. Methods Ninty conscious patients needing nasotracheal intubation,ASA physical Ⅰ orⅡ,aged 18-60 yr,were randomly divided into three groups (n=30):group D,group L and groupDL.The patients in group D were intravenously administered 1.0 μg/kg dexmedetomidine.The patients in group L inhalated nebulized lidocaine 5 mg/kg.The patients in group DL were intravenously administered 1.0 μg/kg dexmedetomidine combined with nebulized lidocaine 5 mg/kg. Intubation conditions, comfort scores, MAP and HR of basis(T0) ,before the intubation(T1), beginning of the intubation(T2), insertion into the trachea immediately(T3) and adverse reactions, such as cough, nausea, restless were recorded. The petients were followed up for the memories of intubation after operation. Results Compared with group DL, the intubation conditions and comfort scores were significantly poor in group D and group L. Compared with T0 and T1, MAP and HR in group D and group L significantly increased at T2 and T3. Compared with group DL, MAP and HR in group D and group L significantly increased at T2 and T3. Compared with group D and group DL, the incidence of memory of intubation significantly increased in group L. Conclusions Dexmedetomidine combined with nebulized lidocaine inhalation can inhibit the response of conscious patient receiving nasotracheal intubation.
Tsaicj, Chucks,Chenti,et al.A comparison of the effectiveness of dexmedetomidine versus propofol target-controlled infusion for sedation during fibreopticnasotracheal intubation[J]. Anaesthesia,2010,65(3):254-259.
[2]
Shimabukuro A, Satoh K. Airway management with dexmedetomidine for difficult airway. Masui[J]. Anaesthesia, 2007,56(6):681-684.
[7]
Raimr, Parrytm,Dombrovskisa,et al.Remifentanil target-controlled infusion vs propofol target-controlled infusion for conscious sedation for awake fibreoptic intubation:a double-blinded randomized controlled trial[J].Br J Anaesth,2008,100(1):125-130 .
Madhere M, Vangura D, Saidov A. Dexmedetomidine as sole agent for awake fiberoptic intubation in a patient with local anesthetic allergy[J]. Anesth, 2011, 25(4): 592-594.
Tsaicj, Chucks,Chenti,et al.A comparison of the effectiveness of dexmedetomidine versus propofol target-controlled infusion for sedation during fibreopticnasotracheal intubation[J]. Anaesthesia,2010,65(3):254-259.
[7]
Raimr, Parrytm,Dombrovskisa,et al.Remifentanil target-controlled infusion vs propofol target-controlled infusion for conscious sedation for awake fibreoptic intubation:a double-blinded randomized controlled trial[J].Br J Anaesth,2008,100(1):125-130 .
Madhere M, Vangura D, Saidov A. Dexmedetomidine as sole agent for awake fiberoptic intubation in a patient with local anesthetic allergy[J]. Anesth, 2011, 25(4): 592-594.
2015, Vol. 26 
