Inhibitory effect of Gongxuening on myometrial contractions and mechanisms
FU Tao1, WANG Limei2, ZHAO Zhenhu2, SHAN Yajun2, LIU Xiaolan2, and CONG Yuwen2
1.Department of Cardiology, the Affiliated Hospital of Institute of Aviation Medicine of Air Force, Beijing 100089, China; 2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
Abstract：Objective To investigate the mechanism underlying myometrial contraction stimulated by Gongxuening, and to provide reference for rational use of Gongxuening in the treatment of abnormal uterine bleeding.Methods The contraction of the uterus in vitro induced by Gongxuening in rats was observed using isolated uterine tension measurement, and the influence of such potential factors as epinephrine and its receptor modulators on the contraction was studied.Results It was found that epinephrine at the dose of 0.001μg/ml completely inhibited rat myometrial contractions induced by 50 μg/ml Gongxuening, while β1 adrenergic receptor (β1-AR) antagonists atenolol and metoprolol both completely reversed the inhibition by epinephrine. α-AR antagonist phentolamine could not reverse the inhibition by epinephrine during rat myometrial contractions induced by Gongxuening, although it completely inhibited myometrial contractions induced by α-AR agonist methoamine.Conclusions The possible mechanism of rat myometrial contractions induced by Gongxuening may be through inhibition of epinephrine β- AR activation.
傅 涛,王丽梅,赵振虎,善亚军,柳晓兰,从玉文. 宫血宁胶囊引起大鼠子宫平滑肌收缩及其初步影响机制研究[J]. 武警医学, 2017, 28(6): 557-559.
FU Tao, WANG Limei, ZHAO Zhenhu, SHAN Yajun, LIU Xiaolan, and CONG Yuwen. Inhibitory effect of Gongxuening on myometrial contractions and mechanisms. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(6): 557-559.
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