Abstract：Objective To investigate the spontaneous brain activity in patients of diabetes complicated with depressive state using resting-state fMRI.Methods Twenty-nine cases were screened by PHQ-9 as diabetic patients complicated with depressive state (DM-D),while another 25 patients with diabetes mellitus(DM)alone who matched the DMD patients in gender, age, and education were selected as the control group. All the subjects were examined by resting-state fMRI. Fractional amplitude of low-frequency fluctuation (fALFF)was used to compare the changes of spontaneous abnormal brain activity in both groups.Results Compared with the DM group, DM-D group displayed decreased fALFF values in right cerebellum posterior crus2, the right temporal superior, right inferior gyrus, right angular gyrus, right frontal superior,middle, inferior gyrus, right limbic Lobe, right anterior cingulate, right parietal supramarginal gyrus, left parietal precuneus, and in left angular gyrus. However, in the left putamen, left occipital calcarine, left middle occipital gyrus, and left parietal postcentral gyrus, fALFF values were increased. Bivariate correlation analyses indicated that the decreased fALFF values and PHQ-9 self-rating scale scores were negatively correlated in DM-D group.Conclusions This resting-state fMRI study suggests that diabetic patients with depression have more than one abnormal brain activity, which helps to understand the pathophysiological mechanism of diabetic patients with depression.
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