摘要目的 探讨个性化饮食管理对2型糖尿病患者血小板反应蛋白-1(TSP-1)的影响。方法 选取2014-05至2016-02医院收治的2型糖尿病患者112例,随机分为对照组和观察组,每组56例。在原药物治疗方案不变的基础上,对照组患者接受常规饮食宣教与糖尿病饮食,观察组患者接受个性化饮食管理、远程随访等护理措施,对比两组患者治疗前与治疗后12个月的TSP-1水平及临床效果。结果 接受不同护理措施干预12个月后,对照组患者FBG和2 h PBG水平较治疗前改善,观察组患者BMI、FBG、2 h PBG、HbA1c和TSP-1水平均较治疗前改善(P<0.05)。组间比较显示,治疗后观察组患者BMI、FBG、2 h PBG、HbA1c、TSP-1水平和糖尿病微血管病变发生率均低于对照组(P<0.05),此外,观察组治疗后评分显著高于对照组(P<0.01)。结论 个性化饮食管理能够降低2型糖尿病患者血清TSP-1水平,预防糖尿病微血管病变,并改善患者饮食依从性。
Abstract：Objective To investigate the effect of individualized diet nursing on levels of thrombospondin-1 (TSP-1) in patients with type 2 diabetes mellitus. Methods One hundred and twelve cases of type 2 diabetes mellitus treated in our hospital between May 2014 and February 2016 were enrolled in this study and divided into two groups randomly. On the basis of the original drug treatment program, the control group was given routine dietary tips and a diet against diabetes, while patients in the observation group received individualized diet nursing. The two groups of patients were compared before treatment and 12 months after treatment.Results The FBG and 2H levels of patients in the control group were higher after 12 months of different nursing interventions. The levels of BMI, FBG, 2 h, HbA1c and TSP-1 in the observation group were better than those before treatment (P<0.05). A comparison between the two groups showed that levels of BMI, FBG, 2 h, HbA1c, TSP-1 and the incidence of diabetic microangiopathy in the observation group were lower than those in the control group after treatment (P<0.05). In addition, the scores of patients in the observation group were significantly higher than those in the control group (P<0.01).Conclusions Individualized diet nursing can reduce the level of serum TSP-1 in patients with type 2 diabetes, effectively prevent diabetic microangiopathy, and improve the dietary compliance of patients.
孙倩, 边志颖. 个性化饮食管理对2型糖尿病患者血小板反应蛋白-1的影响[J]. 武警医学, 2018, 29(8): 797-799.
SUN Qian, BIAN Zhiying. Effect of individualized diet nursing on thrombospondin-1 in patients with type 2 diabetes mellitus. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(8): 797-799.
Caro-Bautista J, Morilla-Herrera J C, Villa-Estrada F, et al. Adaptación cultural al español y validación psicométrica del Summary of Diabetes Self-Care Activities measure (SDSCA) en personas con diabetes mellitus tipo 2[J]. Aten Primaria, 2016, 48(7):458-467.
[7]
Vancampfort D, Mugisha J, Hallgren M, et al. The prevalence of diabetes mellitus type 2 in people with alcohol use disorders: a systematic review and large scale meta-analysis[J]. Psychiatry Res, 2016, 24(9):394-400.
[8]
Bobbert T, Schwarz F, Fischerrosinsky A, et al. Chemerin and prediction of Diabetes mellitus type 2.[J]. Clin Endocrinol, 2015, 82(6):838-843.
[9]
Aguilar-Salvatierra A, Calvo-Guirado J L, González-Jaranay M, et al. Peri-implant evaluation of immediately loaded implants placed in esthetic zone in patients with diabetes mellitus type 2: a two-year study[J]. Clin Oral Implants Res, 2015, 27(2):156.
[10]
Il M, Takenaka H, Asai J, et al. EPC TSP-1 mediates diabetes induced delay in reendothelialization after arterial injury[J]. 2015,5(suppl1):279-281.
[11]
Kong P, Cavalera M, Frangogiannis N G.The role of thrombospondin (TSP)-1 in obesity and diabetes.[J]. Adipocyte, 2014, 3(1):81.
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