Abstract：Objective To evaluate the clinical efficacy and safety of gabapentin combined with desloratadine in the treatment of simple senile pruritus.Methods Sixty-two cases of senile pruritus patients were selected in our hospital between July 2014 and April 2017, who were randomly divided into the combination group and control group, with 31 cases in each.The combination group was treated with gabapentin combined with desloratadine while the control group was treated with desloratadine alone.After 8 weeks of treatment, the curative effect, pruritus visual analog scale score (VAS), Pittsburgh Sleep Quality Index (PSQI) and adverse reactions were compared between the two groups.Results After 8 weeks of treatment, the total effective rate of the combination group (70.97%) was significantly higher than that of the control group (41.94%), and the difference was statistically significant (P<0.05).There was no significant difference in the VAS score or PSQI score between the two groups before treatment.After treatment, the VAS score and PSQI score were significantly decreased, and the difference was statistically significant (P<0.05).The VAS score of the combination group after treatment was [(3.77±2.68) points], which was significantly lower than that of the control group [(5.10±1.99) points], so the difference was statistically significant (t=-2.207, P=0.031).After treatment, the PSQI score of the combination group [(7.55±1.91) points] was also significantly lower than that of the control group [(11.16±4.19) points], so the difference was statistically significant (t=-4.369, P=0.000). No serious adverse reactions occurred in either group.Conclusions Gabapentin combined with desloratadine in the treatment of senile pruritus can effectively control the symptoms of itching, improve the quality of life of patients, with fewer adverse reactions.
王怀湘, 李建明. 加巴喷丁联合地氯雷他定治疗老年性瘙痒症的疗效和安全性[J]. 武警医学, 2018, 29(10): 935-937.
WANG Huaixiang, LI Jianming. Clinical effect and safety of gabapentin combined with desloratadine in treating senile pruritus. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(10): 935-937.
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