The dinical value of p-wave dispersion in the diagnosis and prognosis of pulmonary arterial hypertension
SUN Jingjie1,2, LUO Peng1, MENG Taojiang3, LI Jiang1
1.Dept of Cardiology,Second Xiangya Hospital of Central South University; 2:Hainan Hospital of PLA General Hospital; 3:Sanya Rehabilitation Center of Joint Service Support Force
Abstract：Objective To explore the dinical value of p-wave dispersion (PWD) in thediagnosis and prognosis evduation of pulmonary arterial hypertension.Methods 103 cases of PAH patients and 30 healthy controls were collected. We measured the PWD of all personnel and collected indicators including blood biochemical indicators, echocardiography, and right-heart catheter hemodynamic parameters. So that we can analyze the change of PWD in each group and its correlation with various indicators. According to the risk assessment form recommended by the 2018 WSPH conference, the severity of PAH patients was divided into three groups: low, medium and high risk, therefore to compare the differences of PWD among the groups. We used ROC curve to evaluate the diagnostic efficacy of PWD on PAH.Results Significant increase in PWD in PAH group(P<0.001). PWD was significantly negatively correlated with mixed venous oxygen saturation and cardiac index (r values were -0.388, -0.331, P values are all <0.05). PWD was positively correlated with right atrial mean pressure and NT-proBNP (r values were 0.321, 0.636, P values are all <0.001).After the risk stratification of PAH patients, it was indicated that the groups of low, medium and high risk in PWD showed significant differences (43.89±9.91, 51.29±6.61, 62.15±10.44, P values are all <0.05), meanwhile there was a positive correlation between PWD and the quantitative value of PAH risk stratification(r=0.592,P<0.001).When PWD> 41.45ms, PWD has the highest sensitivity and specificity for predicting PAH, which are 85.44% and 86.67%, respectively.Conclusions PWD is significantly increased in patients with PAH, and it has a bearing on various indicators related to the diagnosis and prognosis of PAH, suggesting that PWD has certain clinical guiding significance for the diagnosis and prognosis evaluation of PAH patients.
孙敬杰, 罗鹏, 孟涛疆, 李江. P波离散度对肺动脉高压诊断和预后评估的临床应用价值[J]. 武警医学, 2020, 31(4): 303-307.
SUN Jingjie, LUO Peng, MENG Taojiang, LI Jiang. The dinical value of p-wave dispersion in the diagnosis and prognosis of pulmonary arterial hypertension. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(4): 303-307.
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2020, Vol. 31 
