Abstract：Objective To explore the clinical significance of PKD2 and GOLPH3 expression in lung adenocarcinoma. Methods Clinical data of 106 patients with lung adenocarcinoma were collected from June 2014 to June 2018 in the 904th Hospital of Chinese PLA Joint Logistics support Force. The expression of GOLPH3 and PKD2 in lung adenocarcinoma and corresponding adjacent tissues were detected by immunohistochemistry. The expression levels of GOLPH3 and PKD2 in lung adenocarcinoma tissues and their effects on prognosis were analyzed by log-rank test and multivariate COX risk regression model. Results The expression levels of GOLPH3 and PKD2 in lung adenocarcinoma tissues were significantly higher than those in corresponding adjacent tissues (P<0.05). In addition, there was a positive correlation between the expression of GOLPH3 and PKD2 in lung adenocarcinoma. Univariate analysis showed that the expression of GOLPH3 and PKD2, tumor diameter, TNM stage, lymphatic metastasis and tissue differentiation affected the prognosis of the patients. Multivariate analysis showed high expression of GOLPH3 (HR=2.879,95%CI=1.590-5.212, P<0.05), high expression of PKD2 (HR=1.922,95%CI=1.078-3.427, P<0.05) and TNM stage (HR=2.022, 95%CI=1.144-3.573,P<0.05)were the independent risk factors affecting the survival of patients. Conclusions GOLPH3 and PKD2 which are characterized by high expression in lung adenocarcinoma are the independent risk factors affecting the prognosis of patients with lung adenocarcinoma.
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2022, Vol. 33 
