摘要目的 探讨雌激素受体α基因SNP12(rs6932902)位点多态性与隐睾的关系。方法 计算机检索PubMed、Embase、EBSCO、知网、中国生物医学文献数据库、维普及万方数据库(1990-01至2021-05),查找关于激素受体α基因 rs6932902多态性与隐睾患病风险的病例对照研究。收集雌激素受体α基因rs6932902多态性与隐睾相关性的相关病例对照研究,应用STATA 12.0软件进行Meta分析,计算合并比值比(OR)及95% 可信区间(CI),并进行敏感性分析,以及发表偏倚的评价。结果 共纳入4篇病例对照研究,Meta分析结果显示:雌激素受体α基因rs6932902位点多态性与隐睾发生风险相关:基因频率A vs. G[OR=0.987,95%CI(0.594,1.612),P=0.931];显性模型AA+GA vs. GG [OR=0.845,95%CI(0.494,1.446),P=0.539];隐形模型AA vs. GA＋AA [OR=1.946,95%CI(1.005,3.767),P=0.048];共显性模型GA vs. GG[OR=0.729,95%CI(0.451,1.180)P=0.198]共显性模型AA vs. GG[OR=1.863,95%CI(0.947,3.663),P=0.071];超显性模型GG+AA vs. GA[OR=1.549,95%CI(1.150,2.209),P=0.005)]。结论 雌激素受体α基因rs6932902位点多态性与隐睾疾病相关;在隐形遗传或者超显性遗传中,AA基因型或AA+GG基因型可增加隐睾患病的风险。
Abstract：Objective To explore the relationship between SNP12(rs6932902) polymorphism of estrogen receptor α gene and cryptorchidism.Methods The case-control studies involving the association of estrogen receptor α gene rs6932902 polymorphism with the susceptibility to cryptorchidism were retrieved through computer-based search in PubMed, Embase, EBSCO, CNKI, CBM,VIP and Wan Fang Data(1990.01-2021.05).The statistical analysis was performed by STATA 12.0 software. Pooled odds ratio (OR) and 95% confidence interval (CI)were calculated,and the sensitivity analysis and publication bias were carried out.Results A total of four case-control studies were included for the meta-analysis. The analysis revealed that there was a significant association of estrogen receptor α rs6932902 polymorphism with the risk of cryptorchidism A vs. G [OR=0.987,95%CI(0.594,1.612), P=0.931]; dominant model: AA+GA vs. GG [OR=0.845,95%CI(0.494,1.446), P=0.539]; recessive model: AA vs. GA＋AA [OR=1.946,95%CI(1.005,3.767), P=0.048]; co-dominant model: GA vs. GG [OR=0.729,95%CI(0.451,1.180), P=0.198]; co-dominant model: AA vs. GG [OR=1.863,95%CI(0.947,3.663), P=0.071];over-dominant: GG+AA vs. GA [OR=1.549,95%CI(1.150,2.209), P=0.005)].Conclusions Estrogen receptor α rs6932902 polymorphism may be significantly associated with the susceptibility to cryptorchidism. The AA genotype or AA+GG genotype increases the risk of cryptorchidism in either recessive or super dominant inheritance.
李思洁, 宁巍, 王养才. 雌激素受体α基因SNP12(rs6932902)位点多态性与隐睾相关性的Meta分析[J]. 武警医学, 2023, 34(2): 104-107.
LI Sijie, NING Wei, WANG Yangcai. Meta-analysis of the association between estrogen receptor α SNP12 (rs6932902) locus polymorphism and cryptorchidism. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(2): 104-107.
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