Abstract：Objective To analyze the perinatal situation, clinical characteristics and treatment outcome of neonates with congenital syphilis.Methods The clinical data of 15 neonates with congenital syphilis admitted to the Department of Pediatrics of the Fifth Medical Center of Chinese PLA General Hospital from March 2012 to May 2022 were retrospectively analyzed.Results Among 15 neonates with congenital syphilis, the gestational age ranged from 32 to 36 weeks in 9 cases (60.0%) and over 37 weeks in 6 cases (40.0%), and eight cases (53.3%) had a birth weight less than 2500 grams. Among the mothers of the neonates with congenital syphilis, 10 people (66.7%) were unemployed, 11 persons (73.3%) had a middle school education, and 11 mothers (73.3%) did not have prenatal examination and treatment. Among the neonates, skin lesions occurred in 6 cases (40.0%), alanine aminotransferase increased in 6 cases (40.0%), direct bilirubin increase occurred in 5 cases (33.3%), nine cases (60.0%) had different degrees of anemia, 5 cases (33.3%) had thrombocytopenia., nephrotic syndrome occurred in 3 cases (20.0%). Pneumonia was diagnosed in 4 cases (26.7%), leukocyte increased in 6 cases (40.0%), C-reactive protein increased in 13 cases (83.7%), convulsions occurred in 1 case (6.7%), and 3 cases (20%) had abnormal long bone radiography.Conclusions The main cause of mother-to-child transmission of syphilis is the irregular prenatal examination and treatment of syphilis mothers, so it is necessary to strengthen the propaganda during pregnancy and syphilis serological testing. The clinical features of neonatal congenital syphilis are complex and diverse without obvious specificity, so suspected children should receive serological examination of syphilis as soon as possible, and timely diagnosis and standardized treatment will get good outcome.
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2023, Vol. 34 
