Abstract：Objective To explore the clinical characteristics of hyperlipidemic acute pancreatitis (HLAP) and analyze the influencing factors of severe cases.Methods Ninety-seven patients with HLAP and 122 patients with biliary acute pancreatitis (BAP) admitted to the Gastroenterology Department of the Sixth Medical Center of PLA General Hospital from January 2018 to May 2022 were selected as the research subjects. The clinical characteristics of the two groups of patients and the influencing factors of severe cases of HLAP were analyzed.Results Compared with BAP group, HLAP group was characterized by more male cases, higher BMI, more severe cases, and more patients with diabetes and fatty liver; and white blood cells, C-reactive protein, triglycerides, blood glucose, and D-Dimer were higher (P<0.05); serum amylase, alanine transaminase, total bilirubin and glutamyl transpeptidase were lower (P<0.05).Multivariate logistic regression analysis suggested that triglycerides (OR=3.461, 95% CI: 1.122-9.723, P=0.008), C-reactive protein (OR=1.209, 95% CI: 1.030-7.593, P=0.013), D-Dimer (OR=0.687, 95% CI: 0.448-0.819, P=0.022) were independent risk factors for severe HLAP.Conclusions Hyperlipidemic acute pancreatitis often occurs in middle-aged and young men, with a significant increase in triglycerides, mostly accompanied by metabolic syndrome, and a severe inflammatory response. Triglyceride lowering, C-reactive protein and D-Dimer levels are independent risk factors for severe HLAP
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2023, Vol. 34 
