Abstract：Objective To evaluate the clinical efficacy of of Heidilei Decoction combined with imrecoxib (CHDI) on osteoarthritis with wind dampness heat Bi syndrome (OA-WDHB) and its effect on matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs) expression.Methods A total of 63 OA-WDHB patients who attended the Beijing Municipal Corps Hospital of Chinese People's Armed Police Force from April 2021 to April 2023 were selected, and randomly divided into control group (treated with imrecoxib, n=31) and combined drugs group (treated with CHDI, n=32). After 4 weeks of treatment, the pain visual analogue scale (VAS), Western Ontario and McMaster Universities osteoarthritis index (WOMAC) and Lequesne algofunctional index (LAI) in knee joints of patients were evaluated, the improvement rate of clinical efficacy was calculated, and the MMP-9 and TIMP-1 expression and MMP-9/TIMP-1 in serum were detected. The adverse reactions of the two groups during the treatment and disease recurrence within 6 months of follow-up were monitored.Results The clinical efficacy rate in CHDI group (90.6%) were notably elevated as compared to the control group (80.6%) (P<0.05). The VAS, WOMAC, LAI, serum MMP-9 and TIMP-1 expression and MMP-9/TIMP-1 in post-treatment of both groups were evidently improved as compared to those in pre-treatment (P<0.05 or P<0.01). In comparison with the control group, the VAS, WOMAC, LAI, serum MMP-9 and TIMP-1 expression and MMP-9/TIMP-1 were significantly improved in CHDI group after the treatment (P<0.01). The incidence of adverse reactions in CHDI group was 12.4%, which was not statistically significant when compared with 9.6% in the control group (P>0.05). The recurrence rate in CHDI group was 10.3% during the follow-up, which was significantly lower than that in the control group, which was 32.0% (P<0.05).Conclusions The efficacy of CHDI in improving the OA-WDHB symptoms and reducing the disease recurrence rate may be related to its ability to modulate the dynamic balance of MMPs and their inhibitors, TIMPs.
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Castrejón I, Chua J R, Pincus T. A RheuMetric physician checklist to quantitate levels of inflammation, damage and distress on 0-10 visual analogue scales [J]. Clin Exp Rheumatol, 2017, 107(5): 21-25.
Kim M J, Kang B H, Park S H, et al. Association of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) with muscle strength in community-dwelling elderly with knee osteoarthritis [J]. Int J Environ Res Public Health, 2020, 17(7): 2260.
Franchignoni F, Salaffi F, Giordano A, et al. Psychometric properties of self-administered Lequesne Algofunctional Indexes in patients with hip and knee osteoarthritis: an evaluation using classical test theory and Rasch analysis [J]. Clin Rheumatol, 2012, 31(1): 113-121.
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Ko J H, Kang Y M, Yang J H, et al. Regulation of MMP and TIMP expression in synovial fibroblasts from knee osteoarthritis with flexion contracture using adenovirus-mediated relaxin gene therapy [J]. Knee, 2019, 26(2):317-329.
2024, Vol. 35 
