|
|
|
| Short-term efficacy and safety of concurrent docetaxel and cisplatin combined with radiotherapy for patients with non-small-cell lung cancer |
| YUAN Huixin,GENG Li,and LI Huiyuan． |
| Shanxi Provincial Corps Hospital,Chinese People’s Armed Police Forces, Taiyuan 030006,China |
|
|
|
|
Abstract Objective To evaluate the feasiblity and safety of combined docetaxel and cisplatin chemotherapy with a sensitizer and concurrent radio-chemotherapy in stage Ⅲ NSCLC．Methods Sixty patients with inoperable stage Ⅲ NSCLC were treated with docetaxel, cisplatin and radiotherapy．Chemotherapy consisted of intravenously docetaxel 20-25 mg/m2 on days 1, 8, 15, cisplatin 40 mg/m2 on days 1, 8, 15. Radiotherapy was delivered up to a total dose of 66-70 Gy with a 2.0 Gy dose fraction per day, 5 days per week．Sixty patients underwent radiotherapy．Results The overall response rates of primary tumors and mediastinum metastatic nodes were 90.0％ and 70.0％, respectively (P<0.05). The acute side effects in patients were mostly myelosuppression, nausea, vomiting, radiation induced esophagitis and pneumonitis, and liver toxicity．However, all of them were tolerant．Conclusions Combined chemo-radiotherapy has good response and survival as compared with conventional radiotherapy in the treatment of locally advanced non-small-cell lung cancer without aggravating the side effects．Docetaxel and cisplatin should be used as a radiosensitizer.
|
|
Received: 10 November 2012
|
|
|
|
|
|
| ［1］ |
殷蔚伯, 余子豪, 徐国镇.等.肿瘤放射治疗学［M］.4版.北京: 中国协和医科大学出版社, 2008: 599.［2］ Hwang A, Muschel R J.Radiation and the G2 phase of the cell cycle［J］.RadiatRes, 1998, 150(Suppl 5): 852-859.［3］ Dunne A L, Mothersill C, Robson T, et al.Radiosensitization of colon cancer cell lines by docetaxel mechanisms of action［J］.Oncol Res, 2004, 14(9): 447-454.［4］ Koolen S L, Beijnen J H, Schellens J H.Intravenous-to-oral switch in anticancer chemotherapy: a focus on docetaxel and paclitaxel ［J］.Clin Pharmacol Ther, 2010, 87(1): 126-129.［5］ 郑爱青, 郑 培, 于金明, 等, 吉西他滨单药或联合卡铂治疗老年晚期非小细胞肺癌疗效观察［J］.武警医学, 2011, 22(6): 501-504.［6］ 蒋国良.现代肿瘤放射治疗学［M］.上海: 上海科学技术出版社, 2003: 431.
|
| ［1］ |
殷蔚伯, 余子豪, 徐国镇.等.肿瘤放射治疗学［M］.4版.北京: 中国协和医科大学出版社, 2008: 599.［2］ Hwang A, Muschel R J.Radiation and the G2 phase of the cell cycle［J］.RadiatRes, 1998, 150(Suppl 5): 852-859.［3］ Dunne A L, Mothersill C, Robson T, et al.Radiosensitization of colon cancer cell lines by docetaxel mechanisms of action［J］.Oncol Res, 2004, 14(9): 447-454.［4］ Koolen S L, Beijnen J H, Schellens J H.Intravenous-to-oral switch in anticancer chemotherapy: a focus on docetaxel and paclitaxel ［J］.Clin Pharmacol Ther, 2010, 87(1): 126-129.［5］ 郑爱青, 郑 培, 于金明, 等, 吉西他滨单药或联合卡铂治疗老年晚期非小细胞肺癌疗效观察［J］.武警医学, 2011, 22(6): 501-504.［6］ 蒋国良.现代肿瘤放射治疗学［M］.上海: 上海科学技术出版社, 2003: 431.
|
| [1] |
. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(8): 718-719. |
|
|
|
|
2013, Vol. 24 
