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| Effect of amlodipine on the pharmacokinetics of bisoprolol in rats |
| TANG Zhe1,SUN Yukun1,LI Yaohong1,and YANG Yuanyuan2. |
| 1.Department of Pharmacy, Liaoning Provincial Corps Hospital,Chinese People’s Armed Police Forces, Shenyang 110034,China;2.Department of Pharmacy,Sujiatun District Hospital of TCM, Shenyang 110101, China |
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Abstract Objective To study the effect of amlodipine on the pharmacokinetics of bisoprolol in rats. Methods Twelve rats were randomly divided into two equal groups:A and B.Rats of group A were given bisoprolol.Rats of group B were given bisoprolol and amlodipine.Blood samples were taken from the animals for the determination of the plasma concentration of amlodipine by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS).The pharmacokinetics parameters together were calculated using DAS program to evaluate each of the two preparations and the pharrnacokinetic parameters were statistically compared. Results The main pharmacokinetic parameters of the two groups were as follows: Cmax: (513.36?56.02) and (585.21?77.52) ng/ml, t1/2: (1.30?0.51) and (1.51?0.65) h, AUC0-t: (433.70?50.98) and (721.16?218.09) ng/(h穖l), CL/F: (38.02?5.63) and (25.9?5.18) L/(h穔g).The pharmacokinetics parameters of AUC0-t and CL/F showed significant difference between the two groups(P<0.05). Conclusions The LC-MS/MS method is specific and sensitive.The amlodipine has significant effect on the pharmacokinetics of bisoprolol with extending of absorption and excretion in rats.
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Received: 10 June 2012
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陈灏珠.实用内科学［M］.13版.北京:人民卫生出版社,2009:1625-1640.［2］ 张维忠.降压联合治疗的理论和实践问题［J］.中华心血管病杂志,2006,34(4):385-386.［3］ 杨世杰,杨宝峰,王怀良.药理学［M］.北京:人民卫生出版社,2005:335. ［4］ Meredith P A,Eilliott H L.Clinical pharmacokinetics of amlodipine［J］.Clin Pharmacokinet,1992,22(1):22-31.［5］ Fogari R, Zoppi A,Corradi L ,et al.β-blocker effects on plasmalipids during prolonged treament of hypertensive patients with hypercholesteremia［J］.J Cardiovasc Pharmacol,1999,33(4):534-539.［6］ 郭 鹏.左旋氨氯地平联合比索洛尔治疗老年高血压性肥厚型心肌病28例疗效观察［J］. 临床合理用药,2011,7(4):54-55.［7］ 彭 澄,何晓峰,刘慎微.氨氯地平联合比索洛尔治疗肾性高血压23例［J］.医药导报,2009, 28(11): 1456-1458.
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陈灏珠.实用内科学［M］.13版.北京:人民卫生出版社,2009:1625-1640.［2］ 张维忠.降压联合治疗的理论和实践问题［J］.中华心血管病杂志,2006,34(4):385-386.［3］ 杨世杰,杨宝峰,王怀良.药理学［M］.北京:人民卫生出版社,2005:335. ［4］ Meredith P A,Eilliott H L.Clinical pharmacokinetics of amlodipine［J］.Clin Pharmacokinet,1992,22(1):22-31.［5］ Fogari R, Zoppi A,Corradi L ,et al.β-blocker effects on plasmalipids during prolonged treament of hypertensive patients with hypercholesteremia［J］.J Cardiovasc Pharmacol,1999,33(4):534-539.［6］ 郭 鹏.左旋氨氯地平联合比索洛尔治疗老年高血压性肥厚型心肌病28例疗效观察［J］. 临床合理用药,2011,7(4):54-55.［7］ 彭 澄,何晓峰,刘慎微.氨氯地平联合比索洛尔治疗肾性高血压23例［J］.医药导报,2009, 28(11): 1456-1458.
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2013, Vol. 24 
