不同剂量阿托伐他汀对颈动脉粥样硬化的干预效果

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Abstract Objective To study the effect of different dose atorvastatin on carotid atherosclerosis.Methods Eight hundred and sixty old patients with carotid atherosclerosis were randomized into atorvastatin 20 mg group (group A, n=420) and atorvastatin 10 mg group (group B, n=440) for six months. Intima-media thickness(IMT) of carotid artery, hs-CRP, serum lipids were detected before and after treatment for six months. Results IMT of carotid artery, hs-CRP, serum lipids in group A were reduced significantly after theatment compared with those before treatment, and in group A were reduced significantly compared with group B.Overall incidence of cardio-and cerebrovasular events in group A was 9.6% and in group B was 13.6%.Conclusions Atorvastain 20 mg treatment in delaying and reversing the progression of carotid atherosclerosis,and reducing cardio-and cerebrovascular events is superior to atorvastatin 10 mg treatment.

Key words： carotid atherosclerosis antilipidemic agents high sensitivity C-reactive protein intima-media thickness, carotid artery

Received: 26 December 2012

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	Articles by authors
	WANG Chunhua
	CHEN Yang
	WANG Baozhong
	ZHANG Siwei
	and GENG Lulu

Cite this article:

WANG Chunhua,CHEN Yang,WANG Baozhong等. Effect of different dose atorvastain on carotid atherosclerosis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2013, 24(5): 396-397.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2013/V24/I5/396

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