高强度间歇运动训练对急进高原淋巴细胞线粒体自噬的影响

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Abstract Objective To explore the effect of short-term high-intensity interval training (HIT) in plain on mitochondrial autophagy in leukocyte after rush entry into plateau. Methods Thirty male lowlanders were randomly divided into two groups: untrained group (NT, n=15) and HIT group (n=15). Participants in the HIT group run at a high training intensity, 90%-95% heart rate reserve (HRR) for 3 min, with active pauses of 3 min of walking at 45%-50% of HRR. Participants in the HIT group underwent six sessions of HIT for 36 min/d, 7 days per week for 2 weeks. After training, participants in both HIT and NT groups traveled into plateau in the same batch. Activities of mitochondrial complex, PINK1, Bnip3 and Beclin-1 protein expression in leukocyte were measured in plateau at 24 h after entry. Results As compared with NT group, in HIT group, mitochondrial autophagy proteins Bnip3 (100±18 vs 136±32) and Beclin-1(100±19 vs 119±26) expression were significantly elevated(P<0.05). Furthermore, mitochondrial complex Ⅰ, Ⅱ, Ⅳ and ATP synthase activities were significantly elevated (P<0.05), whereas PINK1 protein expression was significantly decreased (P<0.01). Conclusions Short-term HIT in plain can blunt high altitude hypoxia induced mitochondrial impariment and elevated mitochondrial energy metabolism through upregulation of mitochondrial autophagy.

Key words： high-intensity interval training high altitude hypoxia leukocyte mitochondrial autophagy energy metabolism

Received: 22 September 2014

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	Articles by authors
	LIU Jing
	ZHANG Hongying
	DUAN Fuqiang
	PENG Peng
	QIN Yongsheng
	and BO Hai

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LIU Jing,ZHANG Hongying,DUAN Fuqiang等. Effect of high-intensity interval training on mitochondrial autophagy in leukocyte after rush entry into plateau[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2014, 25(12): 1228-1231.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2014/V25/I12/1228

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