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| Effect of flagellum protein derivative CZLC331 on the depressive behavior of mice with ulcerative colitis |
| WANG Huan1, XU Yang1, QU Yawei1, ZHANG Chenggang2, LIU Haifeng1 |
1.Department of Gastroenterology, General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China;
2.Institute of Radiation Medicine, Academy of Military Medical Sciences; State Key Laboratory of Proteomics; Research Center for Military Cognition and Mental Hygiene of Chinese PLA, Beijing 100850, China |
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Abstract Objective To study the effect of flagellum protein derivative CZLC331 on the depressive behavior of mice with ulcerative colitis. Methods UC mice model was established by TNBS enema. Eighteen SPF male Balb/c mice were randomly and equally divided into the control group, UC model group, and CZLC331 treatment group, six mice in each group. Mice depression index was observed by forced swimming test, tail suspension experiment and sugar water consumption experiment. Results For the forced swimming test and tail suspension test, the immobility time in treated mice [(64.7±10.4)s,(62.5±13.9)s]was significantly lower than in the model group[(86.7±16.0)s,(111.3±41.1)s], and significantly higher than in the control group[(21.0±5.3)s,(16.0±8.3)s]. In sugar water consumption experiment, the percentage of sucrose preference in treated mice (66.5±7.3)% was significantly higher than in model group(34.5±4.6)%, and significantly lower than in the control group(77.2±7.7)%. Conclusions CZLC331 can effectively improve the level of depression in mice with ulcerative colitis.
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Received: 08 February 2015
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2015, Vol. 26 
