胰岛素强化治疗改善初诊超重老年2型糖尿病β细胞功能及其机制

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Abstract Objective To investigate the mechanism of effect of short term intensive insulin therapy on βcell functions with newly diagnosed elderly overweight type 2 diabetesmellitus. Methods 112 patients were divided into two groups. 60 patients received therapy of continuous subcutaneous insulin infusion(CSII). 52 patients accepted therapy of oral hypoglycaemic agents(OHA).All patients were tested plasma proinsulin(PI),immunoreactive insulin(IRI),high sensitivity C-reactive protein(hsCRP), tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6)before therapy and after therapy; homoeostasis model assessment basal β-cell function (HOMA B) and insulin resistance (HOMA-IR)were calculated. Results After therapy, HOMA B and HOMA-IR were significantly increased in two groups, compared with before therapy(P＜0.05). PI/IRI(ΔPI/IRI:7.5±1.4 vs 3.8±1.6) and inflammatory fator[ΔhsCRP: 0.9±0.4 vs 0.3±0.1(mg/L)、ΔTNF-α:1.1±0.4 vs 0.4±0.3(ng/L)、ΔIL-6:0.7±0.3 vs 0.4±0.2(ng/L)] were significantly decreased in CSII group after therapy(P＜0.05). Multiple linear regression analysis showed that the decrease in PI/IRI was positively correlated with the decrease in hsCRP,TNF-α and IL-6(P＜0.05). Conclusions The effect of short term intensive insulin therapy on βcell function with newly diagnosed elderly overweight type 2 diabetesmellitus is related to inflammation.

Key words： insulin therapy newly diagnosed type 2 diabetesmellitus β-cell insulin secretion inflammation elderly overweight

Received: 13 December 2014

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	ZENG Jian
	CHEN Xiaojun
	LI Yanmin
	HU Dandan

Cite this article:

ZENG Jian,CHEN Xiaojun,LI Yanmin等. Effect of intensive insulin therapy on βcell functions and inflammatory factor with newly diagnosed elderly overweight type 2 diabetes mellitus[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(5): 482-484.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I5/482

[1]	曾建,陈晓军,李艳敏,等,短程持续胰岛素治疗改善初诊2型糖尿病β细胞分泌与炎症反应的观察[J].第三军医大学学报,2014,36(8):815-820.
[2]	Johnson S L, McEwen L N, Newton C A. The impact of continuous subcutaneous insulin infusion and multiple daily injections of insulin on glucose variability in older adults with type 2 diabetes [J]. J Diabetes Complications,2011,25(4):211-215.
[3]	Calle M C, Fernandez M L. Inflammation and type 2 diabetes[J]. Diabetes Metab,2012,38(3):183-191.
[4]	Krystallenia Alexandraki, Christina Piperi, Christos Kalofoutis, et al.Inflammatory Process in Type 2 Diabetes The Role of Cytokines[J].Annals New York academy of sciences ,2006,1084(11):89-117.
[5]	Akash M S, Rehman K, Chen S. Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus[J]. J Cell Biochem,2013,114(3):525-531.
[6]	朱本章,马卫国.胰岛素的非降糖作用和2型糖尿病[J].实用糖尿病学杂志,2006,2(1):57-64.
[7]	Sun Q, Li J, Gao F. New insights into insulin: The anti-inflammatory effect and its clinical relevance [J]. World J Diabetes,2014,5(2): 89-96.
[8]	Paolisso G. Pathophysiology of diabetes in elderly people [J]. Acta Biomed,2010,81(1):47-53.