血清-腹水白蛋白梯度与门脉高压性胃病的关系

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Abstract Objective To study the serum ascites albumin gradient(SAAG) in patients with portal hypertensive gastropathy(PHG) and evaluate the relationship between PHG and SAAG. Method 127 patients with cirrhotic ascites were divided into PHG group and non-PHG group and their SAAG were comparatively analyzed. The relationship of SAAG between the Child-Pugh classification, MELD score, degree of esophageal varices, portal vein diameter and platelet count to spleen size ratio were analyzed in PHG group. The SAAG was analyzed contrastively on both mild and severe cases in PHG group. The receiver operating characteristic(ROC) curve was drawn to determine the optimal diagnosis threshold value of SAAG for PHG. Results The difference was statistically significant in SAAG between PHG group and non-PHG group. The SAAG was positively correlated with the Child-Pugh classification, MELD score and degree of esophageal varices in PHG group. Also there was statistical significance in diameter of portal vein and platelet count to spleen size ratio for SAAG at different levels, as well as the difference between mild and severe cases of SAAG. By using ROC curve, the optimal diagnosis threshold value of SAAG for PHG was shown to be 18.57 g/L, and sensitivity and specificity be 72.1% and 93.2%. Conclusions SAAG reflects the degree of portal hypertension in the course of PHG. SAAG is of clinical value for prediction of occurrence, judgment of the prognosis of PHG.

Key words： portal hypertensive gastropathy serum ascites albumin gradient liver cirrhosis MELD esophageal varices

Received: 10 February 2015

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	ZHAO Zhi
	LUO Junqing
	LIU Xiaoli
	Duan Zexing

Cite this article:

ZHAO Zhi,LUO Junqing,LIU Xiaoli等. Significance of serum ascites albumin gradient test in portal hypertensive gastropathy[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(6): 573-575.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I6/573

[3]	Mc Cormack T T, Sima J, Eyre B L, et al. Gastriclesions in ortalhypertension: in flammatory gastritis or congestive gastropathy[J]. J Gut, 1985,26(4):1226-1232.
[4]	中华医学会消化病学分会,中华医学会肝病学分会,中华医学会内镜学分会. 肝硬化门静脉高压食管胃静脉曲张出血的防治共识(2008,杭州)[J].中华消化杂志,2008,28(8):551-558.
[1]	Demacedo G F,Ferreira F G,Ribeiro M A,et al.Reliability in endscopic diagnosis of portal hypertensive gastropathy[J].World J Gastrointestndosc,2013,5(7):323-331.
[5]	霍宏蕾,董培玲,范丽娟等.肝硬化门脉高压性胃病临床分析[J].北京医学,2012,34(3):219-220.
[2]	Emma L H.Targeting diureticuse for malignant ascites two case reports highlighting the value of the serum-ascites albumin gradientina palliative setting[J].Pain Sym Man,2010,39(2):7-9.
[3]	Mc Cormack T T, Sima J, Eyre B L, et al. Gastriclesions in ortalhypertension: in flammatory gastritis or congestive gastropathy[J]. J Gut, 1985,26(4):1226-1232.
[6]	孙卫东,任普海,俞生富.血清腹水清蛋白梯度对腹水来源的鉴别诊断价值[J].交通医学,2009,23(5):535-553.
[4]	中华医学会消化病学分会,中华医学会肝病学分会,中华医学会内镜学分会. 肝硬化门静脉高压食管胃静脉曲张出血的防治共识(2008,杭州)[J].中华消化杂志,2008,28(8):551-558.
[7]	Khandwalla H E,Fasakin Y,El-Serag H B.The utility of evaluatinglow serum albumin gradient ascites in patients with cirrhosis[J].Am J Gastroenterol,2009,104(6):1401-1405.
[5]	霍宏蕾,董培玲,范丽娟等.肝硬化门脉高压性胃病临床分析[J].北京医学,2012,34(3):219-220.
[6]	孙卫东,任普海,俞生富.血清腹水清蛋白梯度对腹水来源的鉴别诊断价值[J].交通医学,2009,23(5):535-553.
[8]	ZHEN Peilin,ZHANG Ying,ZHANG Yufeng,et al . Clinicalanalysis of liver cirrhosis with portal hypertensive gastropathy [J].J Prac Med,2010,26(16):3003-3005.
[9]	Kumar A, Mishra S R, Sharma P, et al. Clinical,laboratory,and hemodynamic parameters in portal hypertensive gastropathy: A Study of 254 Cirrhotics[J].Clini Gastroenterol,2010,44(4):294-300.
[7]	Khandwalla H E,Fasakin Y,El-Serag H B.The utility of evaluatinglow serum albumin gradient ascites in patients with cirrhosis[J].Am J Gastroenterol,2009,104(6):1401-1405.
[10]	林尤冠,孙龙. 门脉高压性胃病相关危险因素分析[J].海南医学,2013,24(3):343-344.
[8]	ZHEN Peilin,ZHANG Ying,ZHANG Yufeng,et al . Clinicalanalysis of liver cirrhosis with portal hypertensive gastropathy [J].J Prac Med,2010,26(16):3003-3005.
[9]	Kumar A, Mishra S R, Sharma P, et al. Clinical,laboratory,and hemodynamic parameters in portal hypertensive gastropathy: A Study of 254 Cirrhotics[J].Clini Gastroenterol,2010,44(4):294-300.
[11]	毛华,李瑞.肝硬化门脉高压性胃病相关因素分析[J].实用医学杂志,2013,29(4):595-597.
[10]	林尤冠,孙龙. 门脉高压性胃病相关危险因素分析[J].海南医学,2013,24(3):343-344.
[12]	Qamar A A, Grace N D, Groszmann R J,et al. Platelet count is not apredictor of the presence or development of gastroesophagealvarices in cirrhosis[J]. J Hepatology,2008,47(6):153-159.
[11]	毛华,李瑞.肝硬化门脉高压性胃病相关因素分析[J].实用医学杂志,2013,29(4):595-597.
[12]	Qamar A A, Grace N D, Groszmann R J,et al. Platelet count is not apredictor of the presence or development of gastroesophagealvarices in cirrhosis[J]. J Hepatology,2008,47(6):153-159.