青蒿琥酯治疗晚期视网膜母细胞瘤的临床疗效与安全性

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Abstract Objective To study the clinical effect and safety of artesunate combined with conventional therapeutic schedule for children with advanced retinoblastoma. Methods We summarized clinical data of 11 cases who were treated with artesunate combined with conventional therapeutiy with advanced retinoblastoma as combination group between Octobor 1 2012 to January 31 2014 in the General Hospital of Chinese People’s Armed Police Forces. At the same time, 11 cases of advanced retinoblastoma with single conventional therapeutic schedule were selected as control group. The efficacy and safety were reviewed. Results (1)There were two of four(2/4,50%) cases of successfully reserved eyeball in children with intraocular D-E stage, and two cases in five(2/5,40%) received surgery opportunity with extraocular stage in combination group; two cases(2/7,28.6%) of successful reserved eyeball with intraocular D-E stage in seven patients, and one case(1/3,33.3%) received surgey opportunity with extraocular stage in three children in control group. (2)By the end of February 1,2015, the median progression-free survival and the median overall survival were 18.2 months and 21.8 months respectively in the combination group, which compared with control group(the median progression-free survival was 18.4 months and the median overall survival was 21 months), the difference was not statistically significant. (3)All patients did not show allergic reactions during the artesunate therapy and vital signs were stable. No significant difference was found in toxicity between the the two groups (P>0.05). Cnclusion Preliminary study results show that artesunate used for clinical treatment of advanced RB has certain curative effect without extra side effects.

Key words： retinoblastoma artesunate curative effect safety

Received: 03 March 2015

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	Articles by authors
	ZHANG Yuanyuan
	MIAO Lixia
	SUN Yanfeng
	WANG Jun
	LI Yanshan
	LIU Hongyan
	YUAN Hailian
	ZHANG Xianglan
	YANG Xinji
	LIU Qiuling

Cite this article:

ZHANG Yuanyuan,MIAO Lixia,SUN Yanfeng等. Clinical effect and safety of artesunate in treatment of advanced retinoblastoma[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(7): 712-715.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2015/V26/I7/712

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