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| Clinical evaluation of new quadruplet therapy for Helicobacter pylori eradication |
| GU Yong1, YANG Yan2, WANG Lan1, LI Na1, XI Zengqian1, and DUAN Wei1 |
1.Digestive System Department,Shaanxi Provincial Crops Hospital of Chinese People’s Armed Police Force, Xi’an Shaanxi 710054, China;
.2.Xijing Hospital of Digestive Diseases,Fourth Military Medical University,Xi’an,710032,China |
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Abstract Objective To compare the clinical efficacy and adverse events of three different therapies for Helicobacter pylori (H. pylori) eradication. Methods Four hundred and twenty H. pylori positive patients were randomly assigned into three groups in this open-label, prospective, controlled study. Group A patients received 14-day standard quadruplet therapy (esomeprazole plus colloidal bismuth pectin, amoxicillin and clarithromycin). Group B received 14-day new quadruplet therapy (esomeprazole plus colloidal bismuth pectin, amoxicillin and ring ciprofloxacin). Group C received 10-day sequential therapy (esomeprazole plus amoxicillin for 5 days, followed by esomeprazole plus ciprofloxacin and tinidazole for 5 days). H. pylori eradication rate, reinfection rates and adverse events were assessed at three months and six months after treatment. Results H. pylori eradication rates in group B, group C were significantly higher than in the group A (92.9%, 95.7% vs 85.0%, P<0.05). H. pylori reinfection rates were 10.1%, 6.2%, 7.5%, respectively, with no significant difference between the three groups,at three months after treatment. Six months after treatment, H. pylori reinfection rate in group A was 26.9%, which was significantly higher than in groups B, and C, with a 13.8% and 11.9%, respectively (P<0.05). The incidence rate of adverse events between the three groups was not significantly different. Conclusions Ciprofloxacin-based new quadruple therapy and 10-day sequential therapy are both efficient and safe, with a low reinfection rate and high patient compliance, and can be recommended as first-line anti-H. pylori therapy.
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Received: 11 November 2015
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2016, Vol. 27 
