优化积雪草苷非离子表面活性剂囊泡的处方和工艺

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1101 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To optimize the formulation and preparation technique of asiaticoside non-ionic surfactant vesicles.Methods The thin film evaporation method was used to prepare the asiaticoside niosomes, then taking encapsulation efficiency and drug loading rate as an indicator, a single factor experiment was conducted including prescription and technique factors such as the type and amount of surfactant, dosage of the drug, drug-lipid ratio, incubation time, incubation temperature, speed of the rotary evaporator and so on. The optimized asiaticoside niosomes formulation and preparation process was acquired by orthogonal method and was further verified.Results The results of single factor study showed that the three factors which had greater impact on encapsulation efficiency and drug loading rate were surfactants and the cholesterol ratio (m/m), incubation temperature and incubation time. The optimized asiaticoside niosomes formulation is as follows: asiaticoside dosage is 36 mg with the ratio of lipids as 4∶1, incubation temperature is 30 ℃, incubation time is 30 min.The encapsulation efficiency and drug loading rate of the asiaticoside noisome which was prepared according to the optimized formulation was 89.56% and 25.26% and with a microcosmic morphology of typical smooth vesicles.Conclusions The asiaticoside niosomes prepared by thin film evaporation method shows a well-rounded appearance with good dispersity and rather high encapsulation efficiency and drug loading rate.

Key words： Asiaticoside non-ionic surfactant niosomes thin film evaporation formulation technique

Received: 01 February 2016

ZTFLH:

R944.9

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Yangyang
	GUO Yisha
	CHEN Xiaochu
	WU Yang
	YU Changle
	and ZHANG Li

Cite this article:

ZHANG Yangyang,GUO Yisha,CHEN Xiaochu等. A study on optimize formulation and technique of asiaticoside non-ionic surfactant vesicles[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(6): 557-560.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2016/V27/I6/557

[1]	段晓彦,李宏树,王丽红. 积雪草及其活性成分的国内外研究进展[J]. 武警医学院学报,2009,18(3):252-255.
[2]	吴包金,吴建明,江华.增生性瘢痕退行性变的相关影响因素[J].医学研究杂志,2012,41(3):163-168.
[3]	苏州,秦芳,董子迎.积雪草甙乳膏治疗激光术后面部皮损51例报告[J].山东医药,2005,45(16):34.
[4]	王亮亮,刘培娜,马继伟,等.积雪草颗粒对TGF-β1诱导的肾小管上皮细胞TGF-β1表达的影响[J].山东医药,2009,49(46):13-15.
[5]	Muzzalupo R,Tavano L,Lai F,et al. Niosomes containing hydroxyl additives as percutaneous penetration enhancers:effect on the transdermal delivery of sulfadiazine sodium salt[J].Colloid Surface B,2014,123(1):207-212.
[6]	丁林,王慧云,辛姗姗,等. 复乳冻干法制备甲氨蝶呤囊泡[J].中国药学杂志,2014,49(15):1327-1332.
[7]	张阳阳,李建,张莉.滞留时间法评价促透剂对积雪草苷体外经皮释药特性的影响[J].中国急救复苏与灾害医学杂志,2013,8(7):623-625.
[8]	张阳阳,陈莉,张莉,等. 积雪草苷平衡溶解度和油水分配系数的测定[J].解放军药学学报,2013,29(3):189-191.
[9]	魏丽娟,庄蝶微,崔娜,等.特发性肺纤维化生存影响因素分析[J]. 中日友好医院学报,2015,29(5):297-299.
[10]	金瑞日,鲍晓荣.活性维生素D3对大鼠肾小管间质纤维化的影响及其机制研究[J].中国临床医学,2015,22(6):722-726.
[11]	周彦彬,何花,赵欢喆.甲氨蝶呤非离子表面活性囊泡的构建及表征[J].中国新药杂志,2014,23(16):1946-1950.
[12]	姜树红,戈延茹,汪珠燕.非离子表面活性剂囊泡的研究进展[J].中国现代药物应用,2007,1(11):98-101.
[13]	魏军,张春燕,姚庆强. 氟尿嘧啶 Gemini表面活性剂囊泡的制备及其体外释放研究[J].泰山医学院学报,2013,34(2):85-89.
[14]	Behrooz N. Effect of cholesterol and temperature on the elastic properties of niosomal membranes[J].Int J Pharm,2005,300(1-2):95-101.

[1]	. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(5): 459-460.