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| Association between severe preeclampsia and mononmine oxidase A gene |
| SUN Yan1, HOU Xuejing1,and GUO Hongmei2 |
1.Department of Obstetrics, The First Hospital of Qinhuangdao, Qinhuangdao 066000, China;
2.Department of Stomatology, General Hospital of Chinese People’s Armed Police Force,Beijing 100039,China |
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Abstract Objective To analyze the impact of this polymorphism of monoamine oxidase A(MAO-A) variable number tandem repeat (VNTR) on the risk of severe preeclampsia.Methods Sixty pregnant women wih severe preeclampsia and seventy normal pregnant women were genotyped for MAO-A VNTR polymorphism using PCR-based restriction fragment length polymorphism method.Results Significant differences were not observed between the case group and normal controls in the frequencies of MAO-A VNTR alleles and genotypes.Conclusions There is no significant difference in the allele and genotype frequencies of MAO-A gene between case group and normal controls . Our results show that MAO-A VNTR polymorphism perhaps can no increase the risk of severe preeclampsia.
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Received: 19 April 2015
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2016, Vol. 27 
