高血压患者白细胞内源性硫化氢与糖脂代谢指标的关系

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (681 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the effect of leukocyte-derived hydrogen sulfide on regulation of metabolism in hypertensive person.Methods 212 cases of hypertensive subjectswereenrolled, all these persons came from PLA general hospital from Oct 2012 to Feb 2014. Measure theleukocytic productivity of hydrogen sulfide inhypertensive person. Then, measure the metabolism index such as fetal glucose, TC,TG, HDL-C,LDL-C,insulin and so on and analyze the relationship of the leukocyte-derived hydrogen sulfide and those plasma indexandcompare the difference according BMI or insulin level.Results The leukocytic productivity of hydrogen sulfide of overweight and obesity grouphave difference compared with that with normal BMI(0.49±0.21 vs 0.49±0.35 vs 0.93±0.44,P＜0.05) further analysis show that hypertension with high insulin level has significantly lower hydrogen sulfide level than those of normal(P<0.05),and the leukocytic productivity of hydrogen sulfide exists apparent negative correlation withBMI,insulin level and blood uric acid (P＜0.01); positive correlation with HDL-cI(r=0.205,P＜0.01). The leukocytic productivity of hydrogen sulfide contribute to the change of insulin.Conclusions Leukocyte-derived hydrogen sulfide play role on the regulation of metabolism in hypertension, lower speed of the leukocyte-derived hydrogen sulfide may lead to higher insulin level ,which will worsen the abnormal nutrient homeostasis,speed up the process of hypertension.

Key words： hydrogen sulfide Insulin body mass index hypertension

Received: 06 April 2016

ZTFLH:

R544

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CHEN Yongzeng
	SUN Xiaonan
	HUANG Xianyong
	ZENG Qiang
	and CAI Junyan

Cite this article:

CHEN Yongzeng,SUN Xiaonan,HUANG Xianyong等. The study on the effect of leukocyte-derived hydrogen sulfide in the regulation of metabolismin people of hypertension[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(9): 913-916.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2016/V27/I9/913

[1]	Elshorbagy A K, Kozich V, Smith A D,et al.Cysteine and obesity: consistency of the evidence across epidemiologic, animal and cellular studies[J].Curr Opin Clin Nutr Metab Care,2012,15: 49-57.
[2]	Whiteman M I,Gooding K M,Whatmore J L,et al. Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide[J]. Diabetologia,2010,53:1722-1726.
[3]	Jain S K, David M K, Benjamin L B, et al. Relationship between hydrogen sulfide levels and HDL-c, adiponectin, and potassium level in the blood of health subjects [J]. Atherosclerosis,2012,225: 242-245.
[4]	汤晓萍,杜娟,胡柯铭,等. 男性作业工人血浆硫化氢浓度与尿酸和代谢综合征指标的相关性研究[J]. 现代实用医学,2011, 23(11):1289-1291.
[5]	Zheng M, Zeng Q, Shi X Q, et al. Erythrocytic or serum hydrogen sulfide association with hypertension development in untreated essential hypertension[J]. Chin Med J (Engl),2011,124: 3693-3701.
[6]	Mani S, Li H, Untereiner A, et al. Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis[J]. Circulation, 2013,127: 2523-2534.
[7]	Wu L. Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats[J]. Lab Invest, 2009, 1: 59-67
[8]	Nakatsu D, Horiuchi Y, Kano F, et al. l-Cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2 [J]. Proc Natl Acad Sci USA ,2015,112: E1067-E1076.
[9]	Jain S K. Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation [J].Antioxid Redox Signal, 2010, 11: 1333-1337.
[10]	Manna P, Jain S K. Hydrogen sulfide and l-cysteine increase phosphatidylinositol 3,4,5-triphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (AKT)/protein kinase Ced(PKCed) in 3T3L1 adipocytes[J]. J Biol Chem,2011,286: 39848-39859.
[11]	Okamoto M, Ishizaki T, Kimura T, et al. Protective effect of hydrogen sulfide on pancreatic β-cells [J]. Nitric Oxide,2015, 46: 32-36.
[12]	Xue R, Hao D, Sun J, et al. Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes [J]. Antioxid Redox Signal,2013,19: 5-23.
[13]	Okamoto M, Yamaoka M, Takei M, et al. Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes [J]. Biochem Biophys Res Commun,2013, 442(3-4): 227-233
[14]	胡军,朱琳,杨少娟,等. 硫化氢对2型糖尿病大鼠胰岛素抵抗和脂代谢的影响[J]. 中华实验外科杂志, 2015, 32(1): 54-57.