中药联合TACE对原发性肝癌患者免疫功能的影响

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Abstract Objective To explore the influence of Traditional Chinese Medicine combined with transcatheter arterial chemoembolization (TACE) on immune function in primary liver cancer patients. Methods A total of 80 patients with pathologically-proved PLC were enrolled in this study, and randomly divided into a study group and a control group.The study group was treated with TCM combined TACE, while the control group was treated by TACE alone. Peripheral blood T lymphocyte subsets cells, AFP, CD4⁺CD25⁺ Treg cell, as well as the therapeutic effect, Karnofsky sore (KPS) were determined 24 h before treatment and one, and 4 weeks after treatment. The Results were statistically analyzed.Results At the end of the first week after treatment, the preoperative peripheral T lymphocyte subsets CD3⁺(45.26±2.83) vs (50.16±6.31), CD4⁺(22.65±2.35) vs (27.12±3.36) T cells and CD4⁺/CD8⁺(0.85±0.16) vs (1.16±0.27) in the study group were significantly lower,while CD8⁺(32.48±6.21) vs (27.36±5.64) T cells, CD4⁺CD25⁺(12.65±5.12) vs (9.15±3.63) Treg cells were significantly higher than that before treatment(P＜0.05). However, in control group, the peripheral T lymphocyte subsets CD3⁺, CD4⁺, CD8⁺T cells and CD4⁺/CD8⁺ were not statistically significantly different. After 4 weeks,for two groups, the peripheral T lymphocyte subsets CD3⁺(46.55±3.94) vs (49.33±3.12), CD4⁺(23.13±2.72) vs (25.53±2.52), CD8⁺(25.26±3.52) vs (27.69±5.13) T cells and CD4⁺/CD8⁺(1.13±0.39) vs (1.22±0.16) were significantly different (P＜0.05). Treg cells, AFP, KPS were statistically significantly different when compared with those in the control group (P＜0.05). Conclusions TCM combined with TACE can enhance the immunity and quality of life in patients with primary liver cancer.

Key words： primary liver cancer traditional Chinese medicine transcatheter arterial chemoembolization cellular immune function

Received: 09 March 2016

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	Articles by authors
	MIAO Tongguo
	MA Liwei
	WANG Lijing
	CHEN Wusheng
	SHAO Mingliang
	and DUAN Yusong

Cite this article:

MIAO Tongguo,MA Liwei,WANG Lijing等. Influence of Traditional Chinese medicine combined with transcatheter arterial chemoembolization on immune function of primary liver cancer patients[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(9): 928-931.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2016/V27/I9/928

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