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| Protective effect of trimetazidine on myocardial ischemia-reperfusion injury in patients with acute anterior myocardial infarction |
| BI Ying1, LIU Xinlin1, LIU Xiaowei1, LIU Junxiang1, GAO Bowen2, ZHOU Xin1, 3, and ZHAO Jihong1 |
1.Department of Cardiology, Affiliated Hospital, Logistics College of Chinese People’s Armed Police Force, Tianjin 300162, China;
2.Student Second Troop, Logistics College of Chinese People’s Armed Police Force,Tianjin 300309, China;
3.Tianjin Key Laboratory of Cardiovascular Remodeling and Target Organ Injury,Tianjin 300162, China |
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Abstract Objective To observe the protective effect of trimetazidine on myocardial ischemia reperfusion (I/R) injury in patients with acute anterior myocardial infarction treated with primary percutaneous coronary intervention(PCI).Methods 266 cases of newly diagnosed anterior acute ST segment elevation myocardial infarction were randomly divided into the trimetazidine group (132 cases) and the control group (134 cases). The treatment group received loading-dose trimetazidine of 60 mg before PCI and continued to take trimetazidine(20 mg tid) for three months after PCI. TIMI flow grade and TIMI myocardial perfusion grade(TMPG) of each group were recorded during PCI. The cardiac troponin Ic (cTNI) and creatine kinase-MB (CK-MB) levels of each group were measured 24 hours after operation. Left ventricular ejection fraction was also detected before PCI and at one month and three months after PCI by echocardiographic measurements.Results There were more cases of TIMI-3 blood flow and TMPG-3 myocardial perfusion in the trimetazidine group than in the control group. After PCI, the levels of cTNI[(17.04±1.71)ng/ml vs(14.39±1.42)ng/ml,P=0.001] and CK-MB[(90.32±9.26)U/L vs (82.55±8.04) U/L,P=0.001] in the trimetazidine group were significantly lower than those of the control group. Left ventricular ejection fraction of the trimetazidine group was also significantly higher than that of the control group[(54.81±3.27)% vs(52.26±2.55)%,P=0.001] at three months after PCI.Conclusions Early application of trimetazidine in patients with acute anterior myocardial infarction can reduce ischemia reperfusion (I/R) injury during PCI and long-term use of trimetazidine can improve heart function.
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2017, Vol. 28 
