胶囊内镜用于比格犬上消化道检查方法的建立与初步应用

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Abstract Objective To establish real-time surveillance Methods for capsule endoscopy when used in observing upper gastrointestinal mucosal diseases of Beagle dogs or other larger animals.Methods 1.One end of suture 4-0 was tied with the waist of the capsule endoscope, and the other end was taken from the top of the gastric tube through the lumen and out of the tube from a side hole before the capsule endoscope was pulled against the top of the gastric tube by stretching the line to accomplish a simple reconstruction for PillCam SB2 capsule endoscope; 2. A Beagle dog was narcotized before the gastric tube was used to assist the capsule endoscope into the esophagus and gastric cavity; 3. Glacial acetic acid (40%,40 ml)was administrated intragastrically and the capsule endoscope was used to observe the mucosal changes of the digestive tract.Results 1.The modified capsule endoscope entered the Beagle dog’s esophagus and stomach with the help of the gastric tube, and the capsule endoscope could be controlled when it rested against the top of the gastric tube by stretching the line to change the position and angle of the capsule endoscope; 2. Gavage administration of glacial acetic acid (40%,40 ml) led to the establishment of an acute gastric mucosal lesion model for Beagle dogs ; 3. The capsule endoscope could clearly capture the images of the gastric cavity, observe the apparent changes of gastric mucosa at different time points, making possible real-time surveillance of changes of gastrointestinal acute mucosal lesions of the animal model.Conclusions A method of real-time surveillance of the development of upper gastrointestinal mucosa acute lesions by capsule endoscopy has been established, which can be used to observe the changes of gastric mucosal acute injury of beagle dogs or larger animals.

Key words： experimental beagles acute gastrointestinal mucosal lesions capsule endoscopy real-time monitoring establishment and application of method

Received: 08 October 2016

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I2/139

[1]	Rossi G, Ruggiero P, Peppoloni S, et al. Therapeutic vaccination against helicobacter pylori in the beagle dog experimental model: safety, immunogenicity, and efficacy[J]. Infect Immun, 2004, 72(6):3252-3259.
[2]	曾智聪.系线胶囊内镜在急性上消化道出血中的应用价值[D].福州:福建医科大学,2014.
[3]	Liao Z, Gao R, Xu C, et al. Sleeve string capsule endoscopy for real-time viewing of the esophagus: a pilot study (with video)[J]. Gastrointest Endosc, 2009, 70(2): 201-209.
[4]	Ramirez F C, Hakim S, Tharalson E M, et al. Feasibility and safety of string wireless capsule endoscopy in the diagnosis of esophageal varices[J]. Am J Gastroenterol, 2005, 100(5): 1065-1071.
[5]	Ramirez F C, Shaukat M S, Young M A, et al. Feasibility and safety of string,wireless capsule endoscopy in the diagnosis of Barrett’s esophagus[J]. Gastrointest Endosc, 2005, 61(6): 741-746.
[6]	Stipho S, Tharalson E, Hakim S, et al. String capsule endoscopy for screening and surveillance of esophageal varices in patients with cirrhosis[J]. J Interv Gastroenterol, 2012, 2(2): 54-60.
[7]	Chen W S, Zhu L H, Li D Z, et al. String esophageal capsule endoscopy with real-time viewing improves visualization of the distal esophageal Z-line: a prospective, comparative study[J]. Eur J Gastroenterol Hepatol, 2014, 26(3): 309-312.
[8]	Keeratichanaont S, Sobhonsliduk A, Kitiyakara T, et al. The role of liquid simethicone in enhancing endoscopic visibility prior to esophagogastroduodenoscopy (EGD): aprospective, randomized, double-blinded, placebo-controlled trial[J]. J Med Assoc Thai, 2010, 93(8): 892-897.
[9]	田宇瑛,罗明富,徐一慧,等.注入不同刺激性液体建立小型猪胃溃疡模型[J]. 实验动物科学, 2009,26(4):32-34.
[10]	Grigg-Gutierrez N, Laboy C, Ramos L, et al. Diagnostic yield of Video Capsule Endoscopy for small bowel bleeding:eight consecutive years of experience at the VA Caribbean Healthcare System[J]. P R Health Sci J, 2016, 35(2): 93-96.
[11]	Scott R, Enns R. Advances in capsule endoscopy[J]. Gastroenterol Hepatol (N Y), 2015, 11(9): 612-617.
[12]	Collins P D. Video capsule endoscopy in inflammatory bowel disease[J]. World J Gastrointest Endosc, 2016, 8(14): 477-488.
[13]	Yang D H, Keum B, Jeen Y T. Capsule endoscopy for Crohn’s disease: current status of diagnosis and management[J]. Gastroenterol Res Pract, 2016,2016:1-12.
[14]	Santos-Antunes J, Cardoso H, Lopes S, et al. Capsule enteroscopy is useful for the therapeutic management of Crohn’s disease[J]. World J Gastroenterol, 2015, 21(44): 12660-12666.
[15]	Rosa B, Cotter J. Current clinical indications for small bowel capsule endoscopy[J]. Acta Med Port, 2015, 28(5): 632-639.
[16]	Kopylov U,Ben-Horin S, Seidman E G, et al. Video capsule endoscopy of the small bowel for monitoring of Crohn’ s disease[J]. Inflamm Bowel Dis, 2015, 21(11): 2726-2735.
[17]	侯茜.磁控胶囊内镜与传统电子胃镜诊断上消化道疾病的对比研究[D].上海:第二军医大学,2015.
[18]	Wang A, Banerjee S, Barth B A, et al.Wireless capsule endoscopy[J]. Gastrointest Endosc, 2013, 78(6): 805-815.
[19]	Bartzis L, Koulaouzidis A. String-mounted double-headed capsule and Z-line detection: is string really the thing?[J]. Eur J Gastroenterol Hepatol, 2014,26(6): 685-686.