研究植物乳杆菌对肠道细菌易位的抑制作用

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Abstract Objective To investigate the ability of Lactobacillus plantarum L2 to prevent intestinal ischemia and reperfusion induced bacterial translocation.Methods 32 SD rats were randomly divided into four groups: sham, Lactobacillus intragastric administration, ischemia and reperfusion (I/R) model, Lactobacillus pre-treatment and I/R model. The bacterial translocation, changes of gut microflora, levels of proinflammatory cytokines in plasma and intestinal morphology were observed.Results The increase in bacterial translocation was significant after 4 h I/R treatment (P<0.01) as compared with sham-operated group. There were obvious pathological changes of mucosal morphology in I/R rats and the number of anaerobic bacteria such as Bifidobacteria, Lactobacillus and Bacteroides was significantly reduced. The level of TNF-α in plasma was increased after I/R injury. Lactobacillus plantarum treatment alone had no effect on intestinal barrier function. However, pretreatment of rats with Lactobacillus plantarum L2 significantly abrogated I/R induced intestinal mucosal injury and prevented translocation of bacteria to mesenteric lymph nodes or to remote organs.Conclusions Lactobacillus plantarum L2 has the ability to prevent bacterial translocation and attenuate I/R induced intestinal injury.

Key words： Lactobacillus plantarum prevent gut ischemia and reperfusion bacterial translocation

Received: 17 September 2016

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R378.2

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	Articles by authors
	LI Jingjing
	YOU Huanhuan
	WANG Dan
	ZHAO Yongfeng
	and WANG Bin

Cite this article:

LI Jingjing,YOU Huanhuan,WANG Dan等. Lactobacillus plantarum prevents bacterial translocation induced by intestinal ischemia and reperfusion injury in rats[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(3): 240-243.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I3/240

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