2型糖尿病周围神经病变的危险因素及相关炎性反应因子分析

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (701 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective Analyze the prevalence situation of Diabetic Peripheral Neuropathy in type 2 diabetes mellitus, study the related risk factors and inflammatory factors.Methods From January 2015 to July 2016,according to DPN diagnostic criteria ,the patients were diagnosed as type 2 diabeteswere divided into diabetic peripheral neuropathy group and non group. Respectively,check whether combined with diabetic retinopathy and peripheral vascular disease, then analysis of age, weight, BMI, course of disease,biochemical indicator,meanwhile, analyse single factor of each index, and then Logistic multivariate analysis.Results (1)The prevalence of diabetic peripheral neuropathy in the study population was 65.9%; (2)The number of combined with peripheral vascular disease in the diabetic peripheral neuropathy group(69%) was significantly higher than that in non diabetic peripheral neuropathy group (50%),through the χ² test,the difference was statistically significant (χ²=5.723,P<0.05); (3)compared with non group,in the analysis of various factors,the HbA₁c、LDL-C、IL-6、TNF-α、SIL-2R and disease course of diabetic peripheral neuropathy group was statistically significant (t=2.084~3.407,P<0.05).But there was no statistically significant difference compared to other factors.(4)Logistic multivariate analysis:Course、HbA₁c、LDL-C、TNF-α、SIR-2R and combined with peripheral vascular disease are independent risk factors for DPN (OR=0.455~1.655,P<0.05).Conclusions The extension of the disease course, peripheral vascular disease, and blood glucose, blood lipid levels and related inflammatory factors of abnormal, will make diabetic neuropathy exacerbations.

Key words： type 2 diabetes mellitus diabetic peripheral neuropathy risk factors inflammatory factors

Received: 09 October 2016

ZTFLH:

R589.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	GUO Yang
	SONG Xiao
	SHI Xiaoyun
	and WANG Li

Cite this article:

GUO Yang,SONG Xiao,SHI Xiaoyun等. Risk factors and related inflammatory factors analysis of diabetic peripheral neuropathy in patients with ty[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(3): 283-286.

URL:

http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2017/V28/I3/283

[1]	王国民,徐宁,尹冬,等.糖尿病周围神经病变的诊断和治疗新进展[J].中国全科医学,2012,15(5):1661-1663.
[2]	马学毅.糖尿病神经病变的诊断与治疗[J].中国糖尿病杂志,2002,10( 5):300-302.
[3]	Xu Y,Wang L,He J.Prevalence and control of diabetes in Chineseadults[J].JAMA,2013,310(9):948-959.
[4]	朱东,鲁丽利,张剑丰,等.糖尿病患者免疫功能改变与预防肺部感染的临床研究[J].中华医院感染学杂志,2015,25(8):1790-1792.
[5]	Vincent A M, Hayes J M, McLean L L, et al. Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1[J].Diabetes,2009,58(10):2376-2385.
[6]	Coulson W F. Statin neuropathy[J].Fam Pract,2011,60(4):182-184.
[7]	Chong P H, Boskovich A, Stevkovic N. Statin-associated peripheral neuropathy: review of the literature[J].Pharmacotherapy,2004,24(9):1194-1203.
[8]	Gaist D, Jeppesen U, Andersen M, et al.Statins and risk of polyneuropathy: a case-control study[J].Neurology,2002,58(9):1333-1337.
[9]	Singh R, Kishore L, Kaur N. Diabetic peripheral neuropathy: current perspective and future directions[J].Phar Res,2014,80(2):21-35.
[10]	Fromont A, De Seze J, Fleury M C, et al. Inflammatory demyelinating events following treatment with anti-tumor necrosis factor[J].Cytokine,2009,45(2):55-57.
[11]	Barak V, Selmi C, Schlesinger M, et al. Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis[J].Autoimmun,2009,33(3-4):178-182.
[12]	Garcia Ruiz P, Canora L, ebrato J, et al. Soluble interleukin-2 and tumor necrosis factor receptor in liver cirrhosis[J].Med Clin (Barc),2004,122(12):441-443.
[13]	Joshi S V, Tambwekar S R, Khadalia K, et al. Role of inflammatory marker interleukin 6 (IL-6) and insulin in diabetes and diabetic neuropathy [J].Bom Hosp,2008,50(3):466-471.
[14]	Halvatsiotis I, Tsiotra P C, Ikonomidis I, et al. Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes[J].Car Dia,2010,23(2):9-10.