AbstractObjective To study the variation of thrombomodulin (TM) and the correlations with the hypersensitivity troponin T(“hsTnT”for short) in patients with acute myocardial infarction(AMI).Methods The case-control method was used to recruit 30 subjects with AMI and another 30 healthy people as the control group. Enzyme-linked immunoassays were used to detect TM and SPSS was used for data analysis.The correlations between TM and hsTnT were studied.Results TM,creatinine and TM/creatinine ratio were increased in patients with AMI (P<0.05), and TM and TM/Cr ratio were positively correlated with hsTnT (r=0.524,P<0.05;r=0.725,P<0.05).Conclusions TM is increased in patients with AMI, and TM/Cr ratio can be used as a molecular marker ofacute myocardial infarction.
Sapru A, Calfee C S, Liu K, et al. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome [J]. Intensive Care Med, 2015, 41 (3):470-478.
[3]
Yasuaki D, Masuo O, Masaya S,et al. Circulating thrombomodulin levels are related to latent progression of atherosclerosis in hypertensive patients [J]. Hypertens Res,2003,26(6):479-483.
[4]
Yutaka E, Satoshi G, Hiroyasu I, et al.Post-marketing surveillance data of thrombomodulinalfa: sub-analysis in patients with sepsis-induced disseminated intravascular coagulation[J]. J Intensive Care, 2014, 2(30):1-10.
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