氟比洛芬酯联合地佐辛用于腹腔镜胆囊手术的镇痛效果

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Abstract Objective To investigate the efficacy of flurbiprofenaxetil combined with dezocine during gallbladder removal surgery. Methods One hundred patients of ASAⅠ－Ⅱ undergoing gallbladder removal surgery were randomly assigned to four groups(n=25):flurbiprofenaxetil group, dezocine group, flurbiprofenaxetil combined with dezocine group and control group. Before anesthesia induction, flurbiprofenaxetil 1.5 mg/kg was injected intravenously in flurbiprofenaxetil group， dezocine 0.15 mg/kg in dezocine group, flurbiprofenaxetil 1.5 mg/kg combined with dezocine 0.15 mg/kg in flurbiprofenaxetil combined with dezocine group,while an equal volume of saline was given in control group. The extubation time and visual analgesia scale scores were recorded at 2,4,6,12 and 24 h after operation.The incidence of adverse reactions was recorded within 24 h. Results The VAS scores at 2,4,and 6 h were lower in flurbiprofenaxetil group and dezocine group than in control group (P<0.05), and were lower in flurbiprofenaxetil combined with dezocine group than in control group at 2,4,6 and 12 h (P<0.05). Compared with control group, the incidence of complications was increased in the other three groups (P<0.05). Compared with flurbiprofenaxetil combined with dezocine group, the incidence of dizziness and somnolence was decreased in flurbiprofenaxetil group(P<0.05), and that of nausea was decreased in dezocine group(P<0.05). Conclusions Flurbiprofenaxetil (1.5 mg/kg) combined with dezocine has (0.15 mg/kg）better analgesic effect, but the adverse reaction rate can increase in patients during gallbladder removal surgery.

Key words： flurbiprofen dezocine cholecystotomy gallbladder removal surgery

Received: 21 April 2017

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	Articles by authors
	HUANG Anning
	CHEN Na
	DING Lili
	and LIU Liping

Cite this article:

HUANG Anning,CHEN Na,DING Lili等. Clinical observation of flurbiprofenaxetil combined with dezocine in patients during gallbladder removal surgery[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(1): 25-27.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I1/25

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[1]	. [J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(8): 709-710.