超声中频穴位导药联合玻璃酸钠注射对膝骨性关节炎患者IL-1β、TNF-α的影响及疗效

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Abstract Objective To explore the effect of ultrasound-mediated acupoint guidance combined with sodium hyaluronate injection on levels of IL-1β and TNF-α in patients with knee osteoarthritis.Methods Sixty patients with knee osteoarthritis of grade I-III using the Kellgren-Lawrence classification were selected and randomly divided into the single injection group and combined drug guidance group, with 30 patients in each. Each group received intra-articular injection of sodium hyaluronate, once a week, for a total of five times. The combined drug guidance group was treated with patch B at Yanglingquan and Xuehai points once a day, for 20 minutes, and for 4 weeks. Before treatment and one week after treatment, the symptoms and signs of the two groups were evaluated by Western Ontario and McMaster Osteoarthritis Questionnaire (WOMAC) scale, the therapeutic effect was evaluated by the criteria of diagnosis and treatment of TCM disease syndrome Gubi, and the contents of IL-1β and TNF-α in the synovial fluid were measured. Adverse reactions during treatment were simultaneously recorded.Results There was no significant difference in WOMAC scores or levels of IL-1β and TNF-αin synovial fluid between the two groups before treatment (P>0.05). After treatment, The WOMAC scores and levels of IL-1β and TNF-α in synovial fluid were significantly lower (P<0.05),and all the three indexes in the combined drug guidance group were significantly lower than those in the single injection group. The difference between the two groups was statistically significant (P<0.05).The total effective rate of the combined drug guidance group was 93.3%, compared to 70.0% in the single injection group. There was significant difference between the two groups (P<0.05).Conclusions Compared with conventional intra-articular injection, the treatment of knee osteoarthritis with sodium hyaluronate injection combined with the ultrasound-mediated acupoint guidance technique can better inhibit the release of such inflammatory factors as IL-1β and TNF-α,thus quickly alleviating clinical symptoms, improving joint function and enhancing the therapeutic effect.

Key words： knee osteoarthritis ultrasonic penetration therapy sodium hyaluronate inflammatory mediators

Received: 20 May 2018

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	MA Jianhua
	WANG Qinglei

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MA Jianhua,WANG Qinglei. Effect of ultrasound-mediated acupoint guidance combined with sodium hyaluronate injection on IL-1β and TNF-α in patients with knee osteoarthritis[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(10): 949-952.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I10/949

[1]	许鹏,张银刚,姚建锋,等.透明质酸钠治疗膝骨性关节炎的临床效果及分析[J].中国修复重建外科杂志,2005,19(3):210-214.
[2]	中华医学会骨科学分会.骨关节炎诊治指南(2007年版)[J].中华骨科杂志,2007, 27(10):793-796.
[3]	蒋协远,王大伟. 骨科临床疗效评价标准[M]. 北京:人民卫生出版社,2005:275-277.
[4]	陈百成,张静. 骨关节炎[M]. 北京: 人民卫生出版社,2004:1.
[5]	Takafuji V A,Howard R D,Ward D L,et al. Modulation of equine articular chondrocyte messenger RNA levels following brief exposures to recombinant equine interleukin-1beta[J].Vet Immunol Immunopathol,2005,106(1-2):23-28.
[6]	Goldring M B, Goldring S R. Osteoarthritis[J]. J Cell Physiol, 2007, 213(3): 626-634.
[7]	李敏,梁翼,吴晓惠,等. 伴骨髓水肿的膝骨性关节炎患者白细胞介素-1β、白细胞介素-6肿瘤坏死因子-α的相关性研究[J]. 中华风湿病学杂志, 2012, 16(2): 107-110.
[8]	Uebelhart D, Williams J M. Effects of hyaluronic acid on cartilage degradation [J]. Curr Opin Rheumatol, 1999, 11(5): 427-435.
[9]	王丽君,邱春,徐岩,等. 中药超声透入治疗膝关节软组织损伤[J]. 现代康复, 2001, 5(9): 118.
[10]	董海欣,谢文霞,叶天申,等.中药超声透入治疗膝关节骨性关节炎的临床观察[J].中华中医药学刊, 2009, 27(6): 1276-1277.