Objective To explore the clinical and endoscopic features of reflux esophagitis(RE) in patients with nasogastric tube feeding.Methods Totally 231 patients diagnosed with RE by endoscopy were collected and assigned to the group with nasogastric tube feeding(Group A,n=156) and the group of patients aged 80 or above(Group B,n=75).All the patients were classified according to the Los Angeles classification of RE and completed symptom questionaires.The incidence and severity of RE and clinical features were analyzed.Results The detection rate of RE was 67.2% in Group A and 24.4% in Group B,so the difference was statistically significant(χ2=21.23,P<0.05).The percentage of severe cases of RE was 44.3% in Group A and 30.6% in Group B,so the difference was of statistical significance(Z=2.43,P<0.05).There was no statistically significant difference in the incidence of typical symptoms of RE between the two groups,such as heartburn or regurgitation(χ2=3.84,P>0.05).However, the incidence of hematemesis and melena in group A was 37.1% ,compared to 12.0% in Group B,and the difference was statistically significant(χ2=16.61,P<0.05).The incidence of gastric ulcer in Group A was 28.8% and 10.6%in Group B, so the difference was of statistical significance(χ2=9.47,P<0.05).Conclusions Compared with patients aged 80 or above,patients with nasogastric tube feeding have a higher rate of endoscopic detection,fewer typical symptoms(such as heartburn and regurgitation), more atypical symptoms (such as hematemesis and melena),and more severe esophageal inflammation and a higher incidence of gastric ulcer.