鼻用激素缓解季节性过敏性鼻炎眼部症状的疗效观察

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Abstract Objective To observe the therapeutic effect of intranasal corticosteroid mometasone furoate against ocular symptoms of patients with seasonal allergic rhinitis.Methods A total of 156 patients were recruited according to the primary nasal and ocular symptoms of seasonal allergic rhinitis between August 2016 and April 2017. We made a four-grade (none=0, mild=1, moderate= 2, severe=3) self-assessment scale. The first score was assessed by physicians as baseline before administration. Then, the patients received momestasone furoate spray 200 μg once daily (50 μg twice for one nostril), and the nasal and ocular symptom scores were assessed by patients before daily administration. The total nasal and ocular scores were calculated and compared with baseline to assess the therapeutic effect.Results 103 patients completed the study. The total nasal and ocular symptom scores were reduced remarkably 24h after the first medication. The total nasal symptom score became stable after medication twice, and the total ocular symptom score became stable after four-time medication. The significant difference of the total nasal and ocular symptom scores between these groups was confirmed with ANOVA (nasal symptom: F=533.500,P＜0.01; ocular symptom: F=362.188,P＜0.01). No adverse events were found during the treatment.Conclusions Intranasal corticosteroin mometasone furoate can relieve both nasal and ocular symptoms significantly. This single agent can be used to relieve the symptoms of seasonal allergic rhinitis with ocular problems effectively.

Key words： seasonal allergic rhinitis intranasal corticosteroid mometasone furoate nasal-ocular symptoms

Received: 04 February 2018

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LI Xuesheng.. Alleviation of ocular symptoms with intranasal corticosteroid among seasonal allergic rhinitis patients[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2018, 29(9): 861-863.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2018/V29/I9/861

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