系统性红斑狼疮早发动脉粥样硬化模型小鼠的建立

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Abstract Objective To explore a mouse model of premature atherosclerosis in systemic lupus erythematosus (SLE). Methods Twelve-week-old ApoE^-/- mice were randomly divided into the model group and control group.The mouse model was injected with pristane intraperitoneally while the control group was injected with normal saline. After 8 weeks of high fat diet (HFD), all the animals were sacrificed, and the levels of creatinine, urea nitrogen, total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C) were detected using some commercial kits. Hematoxylin (HE) staining was used to observe the morphological changes of kidney tissue. Results Compared with the control group, TC, TG, and LDL-C were increased from (6.52±3.40)mmol/L, (0.49±0.14)mmol/L and(0.30±0.30)mmol/L to (17.53±2.32) mmol/L,(1.03±0.21) mmol/L and (1.25±0.30) mmol/L respectively (P＜0.01), while the level of HDL-C was down from (1.66±0.17)mmol/L to (0.79±0.17)mmol/L (P＜0.01).The levels of creatinine and urea nitrogen were increased significantly. Meanwhile, the renal pathological damage was very severe in the model group. Conclusions A mouse model of premature atherosclerosis in SLE can be established through the intraperitoneal injection with pristane in ApoE^-/- mice, which will contribute to the treatment and prevention of premature atherosclerosis in SLE.

Key words： atherosclerosis systemic lupus of erythematosus ApoE^-/- mouse immune response

Received: 10 October 2018

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	GUO Xiaoling
	ZHU Chunhong

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GUO Xiaoling,ZHU Chunhong. A mouse model of premature atherosclerosis in systemic lupus erythematosus[J]. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(4): 308-310.

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http://journal08.magtechjournal.com/Jwk_wjyx/EN/ OR http://journal08.magtechjournal.com/Jwk_wjyx/EN/Y2019/V30/I4/308

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